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Azole-resistant Aspergillus fumigatus in Denmark: a laboratory-based study on resistance mechanisms and genotypes  R.H. Jensen, F. Hagen, K.M.T. Astvad,

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Presentation on theme: "Azole-resistant Aspergillus fumigatus in Denmark: a laboratory-based study on resistance mechanisms and genotypes  R.H. Jensen, F. Hagen, K.M.T. Astvad,"— Presentation transcript:

1 Azole-resistant Aspergillus fumigatus in Denmark: a laboratory-based study on resistance mechanisms and genotypes  R.H. Jensen, F. Hagen, K.M.T. Astvad, A. Tyron, J.F. Meis, M.C. Arendrup  Clinical Microbiology and Infection  Volume 22, Issue 6, Pages 570.e1-570.e9 (June 2016) DOI: /j.cmi Copyright © Terms and Conditions

2 Fig. 1 Overview of Aspergillus fumigatus isolates (left) referred to Statens Serum Institut since 2010 and corresponding patients (right). Colours indicate whether isolates (from corresponding patients) were screened for azole resistance (grey, susceptible; red, resistant) or not (white). All isolates were counted, but patients were not counted twice if same resistant isolate was detected, even if different calendar years. Red numbers above each bar indicate percentage of resistance (among susceptibility tested isolates). Chi-square test was used to test for trend in proportions. *p <0.05, **p <0.001. Clinical Microbiology and Infection  , 570.e1-570.e9DOI: ( /j.cmi ) Copyright © Terms and Conditions

3 Fig. 2 Minimum spanning tree of short tandem repeat Aspergillus fumigatus (STRAf) genotyped Danish A. fumigatus isolates including all nine markers. Each circle represents unique genotype. Heavy connecting lines indicate similarity in eight of nine microsatellites. (A) Danish overview illustrating genotypes from azole-susceptible and -resistant isolates as well as clinical and environmental isolates. Furthermore, Roskilde outbreak and seven incidents of shared STRAf genotypes between unrelated isolates have been indicated. RH, University Hospital Copenhagen, Rigshospitalet. (B) Black-and-white representation of Danish genotypes with national flags of where A. fumigatus has been uncovered sharing identical STRAf genotypes on all nine markers. Numbers and percentages in parentheses indicate number of genotypes/total from each country, which are identical to Danish STRAf genotypes. Clinical Microbiology and Infection  , 570.e1-570.e9DOI: ( /j.cmi ) Copyright © Terms and Conditions


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