1. Glycogen Metabolism
Title slide - metabolism of glycogen

2. Glycogen has a branched structure.

3. Chemical formula and another depiction of the branched glycogen structure.

4. 1,4 & 1,6 glycosidic linkages.

5. Glycogen phosphorylase views.

6. The reaction catalyzed by glycogen phosphorylase

7. The reaction mechanism.

8. Function of the debranching enzyme.

9. Formation of UDPG.

10. Conformational change in glycogen phosphorylase

11. The branching enzyme - makes the branches.

12. Glycogen synthase and the branching enzyme

13. Details of glycogen synthase

14. Glucose to glycogen.

15. Two second messengers DAG & Itris phoshate

16. Regulation

17. A monocyclic cascade.

18. The major modifying and demodifying reactions controlling glycogen metabolism.

19. Ribbon structure pf the C subunit of protein kinase.

20. Antagonism between insulin and epinephrine on glycogen metabolism.

21. F2,6BP formation and degradation.

22. Multiple regulatory circuits can mobilize glucose from glycogen.

23. Glycogen’s glucose can be completely oxidized.

24. Details of glycogen synthase.

25. Control of interconversion of phosphorylase a and b forms.

26. Control of glycogen synthase a and b.

27. Cascade effects

28. Glucose can be a signal; liver cell.

29. Mobilization of glucose from glycogen in liver.

30. Muscle cell uses its glycogen for energy.

31. Mediation of nerve excitation by calcium.

32. Insulin in liver.

33. Insulin in muscle.