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by Franz F. Wagner, and Willy A. Flegel

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1 by Franz F. Wagner, and Willy A. Flegel
RHCE represents the ancestral RHposition, while RHD is the duplicated gene by Franz F. Wagner, and Willy A. Flegel Blood Volume 99(6): March 15, 2002 ©2002 by American Society of Hematology

2 RH locus in human and mouse
RH locus in human and mouse.The human RH locus (top) is compared to the mouseRH locus (bottom). RH locus in human and mouse.The human RH locus (top) is compared to the mouseRH locus (bottom). The orientations and positions of genes are indicated by gray arrows, the rhesus boxes by white triangles. The fragment of the mouse RH gene shown covers exons 2 to 10. An open reading frame (ORF) in the rhesus box is depicted as a black circle, the succinate dehydrogenase complex, subunit D precursor pseudogene in RH intron 3 as a white circle; no sequences homologous to these ORF were found in the mouse locus. During the duplication event, RHD and its fringing rhesus boxes were inserted between NPD014 and SMP1. The depicted DNA segments are GCIP-binding protein P29 (accession numbers human, NM_015484; mouse, AY033432), NPD014 (AF247168,AK003799), SMP1 (NM_014313, AK014282) and RH(CE)(M34015, NM_011270), and the ORF in the upstream and downstream rhesus boxes (XP_ and XP_057505). Franz F. Wagner, and Willy A. Flegel Blood 2002;99: ©2002 by American Society of Hematology

3 Topology of SMP1 and RHCE
Topology of SMP1 and RHCE.The orientations and positions of the genes are indicated by gray arrows and the localization of the exons by black lines at their approximate scale. Topology of SMP1 and RHCE.The orientations and positions of the genes are indicated by gray arrows and the localization of the exons by black lines at their approximate scale. The relative position and orientation ofRHCE and SMP1 is conserved. Human and mouseSMP1 have a very similar topology. Both human rhesus genes are much enlarged relative to the mouse RH gene because of considerably elongated introns. Franz F. Wagner, and Willy A. Flegel Blood 2002;99: ©2002 by American Society of Hematology

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