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99mTc-HL91 by Robert D. Okada, Gerald Johnson, Kiem N. Nguyen, Zhonglin Liu, Barbara Edwards, Colin M. Archer, Timothy L. North, Adam C. King, and James.

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Presentation on theme: "99mTc-HL91 by Robert D. Okada, Gerald Johnson, Kiem N. Nguyen, Zhonglin Liu, Barbara Edwards, Colin M. Archer, Timothy L. North, Adam C. King, and James."— Presentation transcript:

1 99mTc-HL91 by Robert D. Okada, Gerald Johnson, Kiem N. Nguyen, Zhonglin Liu, Barbara Edwards, Colin M. Archer, Timothy L. North, Adam C. King, and James D. Kelly Circulation Volume 97(25): June 30, 1998 Copyright © American Heart Association, Inc. All rights reserved.

2 Experimental protocol used for this study.
Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.

3 Mean best-fit linear regression lines for 2 phases of microsphere flow vs 99mTc-HL91 myocardial activity data. Mean best-fit linear regression lines for 2 phases of microsphere flow vs 99mTc-HL91 myocardial activity data. Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.

4 Mean 99mTc-HL91 myocardial time-activity curves determined by ROI analysis of serial gamma camera images. Mean 99mTc-HL91 myocardial time-activity curves determined by ROI analysis of serial gamma camera images. LCx indicates LCx myocardial zone; LAD, LAD myocardial zone. Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.

5 99mTc-HL91 count ratios over time determined by ROI analysis of serial gamma camera images.
99mTc-HL91 count ratios over time determined by ROI analysis of serial gamma camera images. LCx/LAD indicates LCx/LAD myocardial zones; LCx/lung, LCx myocardial zone/lung; and LCx/liver, LCx myocardial zone/liver. *P<0.05 vs time zero. Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.

6 Ex vivo gamma camera 99mTc-HL91 images from 4 slices after euthanasia for 1 representative dog.
Ex vivo gamma camera 99mTc-HL91 images from 4 slices after euthanasia for 1 representative dog. The entire heart is shown in the left image with LCx to the left. Slices are arranged with base at upper right, slice 2 upper left, slice 3 lower right, and apex lower left. LCx zone is to right on all slices and LAD zone to left. Images clearly demonstrate increased tracer activity in LCx zone vs LAD zone. Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.

7 Mean 99mTc-HL91 myocardial ex vivo count ratios for whole heart and individual slices after euthanasia. Mean 99mTc-HL91 myocardial ex vivo count ratios for whole heart and individual slices after euthanasia. Ratio is for LCx zone/LAD zone. Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.

8 99mTc-HL91 time-activity curve for blood.
Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.

9 Microsphere flow vs 99mTc-HL91 myocardial activity curves for each of 8 individual experiments.
Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.

10 In vivo serial gamma camera 99mTc-HL91 images from 1 representative dog.
In vivo serial gamma camera 99mTc-HL91 images from 1 representative dog. Top, Images at 30, 60, 90, and 120 minutes. LCx is to left and LAD to right of cardiac images, and liver activity is shown below. Bottom, Images at 150, 180, 210, and 240 minutes. Robert D. Okada et al. Circulation. 1998;97: Copyright © American Heart Association, Inc. All rights reserved.


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