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Is combined resynchronisation and implantable defibrillator therapy a cost-effective option for left ventricular dysfunction?  Mary Bond, Stuart Mealing,

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Presentation on theme: "Is combined resynchronisation and implantable defibrillator therapy a cost-effective option for left ventricular dysfunction?  Mary Bond, Stuart Mealing,"— Presentation transcript:

1 Is combined resynchronisation and implantable defibrillator therapy a cost-effective option for left ventricular dysfunction?  Mary Bond, Stuart Mealing, Rob Anderson, John Dean, Ken Stein, Rod S. Taylor  International Journal of Cardiology  Volume 137, Issue 3, Pages (November 2009) DOI: /j.ijcard Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Structure of the decision analytic model. Legend: Transition to any individual state resulting from either an adverse event or operation. Transition to any individual state within a submodel to an individual state. Transition from an individual state to any state within a submodel. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 a. Distribution of incremental costs versus incremental outcomes for CRT versus medical therapy. Solid line indicates a willingness to pay threshold of £30,000/QALY. b. Cost-effectiveness acceptability curves for CRT versus medical therapy. The descending curve represents medical therapy and the ascending curve CRT. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 a. Distribution of incremental costs versus incremental outcomes for CRT–ICD versus CRT. The solid line indicates a willingness to pay threshold of £30,000/QALY. b. Distribution of incremental costs versus incremental outcomes for CRT–ICD versus CRT. The descending curve represents CRT and the ascending curve CRT–ICD. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Cost-effectiveness frontier of medical therapy versus CRT versus CRT–ICD. The left descending curve represents medical therapy; the central curve CRT and the right ascending curve CRT–ICD. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 5 a. Threshold analysis of CRT–ICD versus CRT cost-effectiveness and risk of sudden cardiac death at implant. b. Threshold analysis of CRT–ICD versus CRT cost-effectiveness and age at time of implant. International Journal of Cardiology  , DOI: ( /j.ijcard ) Copyright © 2008 Elsevier Ireland Ltd Terms and Conditions

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