1. Med Chem Tutoring for AEDs
By Alaina Darby

2. Which of the following R” groups would be suitable for partial seizures?
Methyl
Ethyl
Benzene
Propyl C

3. Which of the following is not a prodrug?B
A Mephobarbital… must demethylate
C Primidone… must add oxygen

4. Decreases sodium influx into excitable tissues Membrane-stabilization
Which of the following would not true of hydantoins mechanism of action?
Decreases sodium influx into excitable tissues
Membrane-stabilization
Decrease in membrane permeability to Ca2+
Decrease of excitatory NT from postsynaptic vesicles C

5. Why is phenytoin not recommended for preschool aged children?
Gingival hyperplasia
Osteomalacia
Megoblastic anemia
Sedation A

6. Why would fosphenytoin be considered over phenytoin?
Concerns with gingival hyperplasia
Need to administer with a basic drug
Need to administer with an acidic drug
Need to use for absence seizures B

7. Which of the following is not a side effect of phenytoin? SJS TEN
Teratogenicity
Sedation D

8. Which of the following can be used for absence seizures? Ethosuximide
Methsuximide
Phenytoin
Phenobarbital A

9. Which of the following is the benzodiazepine that can be formulated most easily as an injectable?
Lorazepam
Midazolam
Diazepam
Clonazepate
B (the imidazole is much more basic so it can form a salt)

10. Which of the following is a prodrug? Lorazepam Midazolam Diazepam
Clonazepate D

11. Which of the following causes the most hepatotoxicity? Phenytoin
Phenobarbital
Valproic Acid
Carbamazapine C

12. Which of the following does not cause a rash due to its reactive metabolites?
Phenytoin
Ethosuximide
Valproate
Carbamazapine B

13. Which of these does not form an epoxide metabolite? Phenytoin
Ethosuximide
Valproate
Carbamazapine B

14. Which of the following would not be contraindicated if a patient is allergic to TMP-SMX?
Acetazolamide
Gabapentin
Zonisamide
Topiramate B

15. Which of the following can cause kidney stones? Acetazolamide
Gabapentin
Zonisamide
Topiramate D

16. Which of the following can undergo benzylic hydroxylation?
Acetazolamide
Gabapentin
Pregabalin
Tigabine D

17. Which of the following may effect CYPs? Zonisamide Gabapentin
Levetiracetam
Tigabine A

18. Which of the following does not induce CYP3A4? Rufinamide Valproate
Phenobarbital
Phenytoin B