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A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis 

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Presentation on theme: "A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis "— Presentation transcript:

1 A Phase 2, Double-Blind, Placebo-Controlled, Randomized Study of Fresolimumab in Patients With Steroid-Resistant Primary Focal Segmental Glomerulosclerosis  Flavio Vincenti, Fernando C. Fervenza, Kirk N. Campbell, Montserrat Diaz, Loreto Gesualdo, Peter Nelson, Manuel Praga, Jai Radhakrishnan, Lorenz Sellin, Ajay Singh, Denyse Thornley-Brown, Francisco Veríssimo Veronese, Beverly Accomando, Sara Engstrand, Steven Ledbetter, Julie Lin, John Neylan, James Tumlin  Kidney International Reports  Volume 2, Issue 5, Pages (September 2017) DOI: /j.ekir Copyright © 2017 International Society of Nephrology Terms and Conditions

2 Figure 1 Consolidated Standards of Reporting Trials (CONSORT) diagram.
Kidney International Reports 2017 2, DOI: ( /j.ekir ) Copyright © 2017 International Society of Nephrology Terms and Conditions

3 Figure 2 (a) Estimated mean percent change in urinary protein/creatinine ratio (Up/c) from baseline to day 112/visit 6 by treatment assignment. (b) Mean (± SE) percent change from baseline in estimated glomerular filtration rate (eGFR) over time by treatment assignment. Kidney International Reports 2017 2, DOI: ( /j.ekir ) Copyright © 2017 International Society of Nephrology Terms and Conditions

4 Figure S1 Focal segmental glomerulosclerosis (FSGS) patients assigned to 1 mg/kg (n = 14). Kidney International Reports 2017 2, DOI: ( /j.ekir ) Copyright © 2017 International Society of Nephrology Terms and Conditions

5 Figure S2 Focal segmental glomerulosclerosis (FSGS) patients assigned to placebo (n = 10). Kidney International Reports 2017 2, DOI: ( /j.ekir ) Copyright © 2017 International Society of Nephrology Terms and Conditions

6 Figure S3 Focal segmental glomerulosclerosis (FSGS) patients assigned to 1 mg/kg with > 1 partial remission event (n = 6). Kidney International Reports 2017 2, DOI: ( /j.ekir ) Copyright © 2017 International Society of Nephrology Terms and Conditions

7 Figure S4 Focal segmental glomerulosclerosis (FSGS) patients assigned to 4 mg/kg (n = 12; 3 treated with other immunosuppressant medications). Kidney International Reports 2017 2, DOI: ( /j.ekir ) Copyright © 2017 International Society of Nephrology Terms and Conditions

8 Figure S5 Postinfusion fresolimumab serum concentrations (mean ± SE).
Kidney International Reports 2017 2, DOI: ( /j.ekir ) Copyright © 2017 International Society of Nephrology Terms and Conditions


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