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Pathways of thromboxane production and the antiplatelet effects of aspirin Dotted arrows denote “bypass” of aspirin’s inhibiton of platelet COX-1 Graeme.

Published byNorman Mills Modified over 5 years ago

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Presentation on theme: "Pathways of thromboxane production and the antiplatelet effects of aspirin Dotted arrows denote “bypass” of aspirin’s inhibiton of platelet COX-1 Graeme."— Presentation transcript:

1 Pathways of thromboxane production and the antiplatelet effects of aspirin Dotted arrows denote “bypass” of aspirin’s inhibiton of platelet COX-1 Graeme J Hankey, John W Eikelboom, Lancet 2006; 367 online

2 Laboratory tests commonly used to measure the antiplatelet effects of aspirin
Graeme J Hankey, John W Eikelboom, Lancet 2006; 367 online

3 Possible causes of aspirin failure
Graeme J Hankey, John W Eikelboom, Lancet 2006; 367 online

4 Possible mechanisms of reduced suppression of thromboxane production (laboratory aspirin resistance)
Graeme J Hankey, John W Eikelboom, Lancet 2006; 367 online

5 Association between elevated urinary 11-dehydrothromboxane B2 and incidence of myocardial infarction, stroke, or cardiovascular death in the HOPE study Graeme J Hankey, John W Eikelboom, Lancet 2006; 367 online

6 Association between reduced inhibition of agonist induced platelet aggregation and incidence of death, myocardial infarction, or stroke Graeme J Hankey, John W Eikelboom, Lancet 2006; 367 online

7 Possible mechanisms of aspirin resistance
Graeme J Hankey, John W Eikelboom, Lancet 2006; 367 online

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