1. IN THE NAME OF GOD

2. Female Horonal Cycle MENSTRUAL CYCLE E.Naghshineh MD

3. Reproductive hormons: GnRH
GnRH: decapeptide, by neurons in arcuate nucleus of hypothalamus
Regulate secretion of two hormones: FSH and LH
Pulsatile secretion
Extremely short half-life: only 2-4 min

4. Gonodotropins LH &FSH: by ant pituitary gonadotroph cells
Ovarian follicular stimulation
Glycoproteins, alpha &beta subunit

5. Prolactin Poly peptide, by ant pituitary lactotroph
Primary trophic factor responsible for the synthesis of milk by breast
PRL secretion is under tonic inhibitory control by hypothalamic secretion of dopamine
PRL stimulation: breast manipulation, drugs, stress, exercise, certain foods

6. TSH By ant pituitary thyrotrophs in response to TRH
TRH:by arcuate nucleus ,portal circulation, pituitary
TRH: TSH & PRL release
Hypo- and hyperthyroidism: ovulatory dysfunction

7. Oxytocin 9 aa peptide, by paraventricular nucleus of hypothalamus
Uterine muscular contraction, breast lactiferous duct myoepithelial contraction

8. MENSTRUAL CYCLE varies from female to female (21-35 days)
Normal cycle length is considered 28 days
varies from female to female (21-35 days)
Ovarian cycle: 1-follicular ,2-luteal
Uterine cycle: 1-proliferative ,2-secreatory

9. 1 – Follicular phase
Development dominant follicle, mature at midcycle, ovulation
Average length:10-14 days
Variability in length: variations in total cycle length

10. 2-luteal phase
Ovulation to menses
Average length: 14 days

11. Normal menstrual cycle
21-35 days
2-6 days of flow
Average blood loss:20-60 ml

13. Hormonal variations
At the beginning of cycle: levels of gonadal steroids are low
Demise of corpus luteum, FSH levels rise, cohort of growing follicles is recruited, rise in estrogen: stimulus for uterine endometrial proliferation

14. 3. Rising estrogen levels: negative feedback on pituitary FSH secretion;
growing follicle produce inhibin-B: suppresses pituitary FSH secretion;
Rising estrogen levels: LH initially decreases
but late in follicular phase LH levels increased dramatically

15. 4.At the end of follicular phase (just before ovulation) FSH-induced LH receptors on granulosa cells;
with LH stimulation, modulate secretion of progesterone

16. 7.Progesteron levels rise after ovulation; presumptive sign of ovulation
8.Progesteron;estrogen and inhibin-A : suppress gonadotropin secretion and new follicular growth

17. 5.After sufficient degree of estrogenic stimulation; pituitary LH surge triggered, proximate cause of ovulation occurs to 36 hours later

18. 6.Estrogen level decreases through the early luteal phase from just before ovulation until midluteal phase,
rise again as a result of corpus luteum secretion

22. Cyclic changes of the Endometrium
Decidua functionalis: 2/3 superficial, proliferate and shed each cycle
Decidua basalis: deepest region, source of endometrial regeneration after each menses

23. 1-Proliferative phase
First day of vaginal bleeding :day 1 of the menstrual cycle
Progressive mitotic growth of decidua functionalis, preparation for implantation of embryo
Thin endometrium (1-2 mm); straight, narrow, short endometrial glands become longer, tortuous structures

24. 2-Secretory phase
48 to 72 hours following ovulation, progesteron secretion: eosinophilic protein-rich secretory product in glandular lumen
Postovulatory day 6-7,maximal secretory activity: optimal for implantation of blastocyst
Stromal edema in late secretory phase

25. 2 days before menses:dramatic increases in PMN migrate from vascular system

26. Menses
Absence of implantations, glandular secretion ceases, irregular break-down of decidua fuctionalis
Destruction of corpus luteum and its productions estrogen and progesteron: cause of shedding
Withdrawal of sex steroids: spiral art spasm, endometrial ischemia, lysosoms breakdown, proteolytic enzymes release

28. Ovarian follicular development
Fetus:6-7 million in 20 wks
At birth:1-2 million
At puberty:300,000
Release during ovulation:
At menopause:rare

30. Oogonia: only one final daughter cell (oocyte), three polar body
Oocyte arrested in prophase (diploten) until time of ovulation

31. Two-cell two-gonadotropin theory: with LH stimulation, the ovarian theca cells produce androgens that convert by granulosa cells into estrogens under the stimulus of FSH

33. THE END