1. ASPARTIC ACID AND ASPARAGINE METABOLISM
By-
Maya Yadav
Roll No.-46
HIMS MBBS Ist Year

2. Aspartic Acid Non-essential amino acid. Glucogenic amino acid.
Acidic amino acid.

3. Source
Our cell can make aspartic acid so it can’t be typically needed as part of our diet.
But it can be supplemented through other sources in diet.
Animal source-
egg, meat and dairy product
Plant source-
Barley,oat, millet, white rice and amaranthus

4. Synthesis
Transamination- Aspartate are synthesized by transfer of amino group to the alpha keto acid oxaloacetate.

5. By Asparagine
Asparagine is converted to aspartate with the help of enzyme asparaginase.

6. Metabolism
N1 is correct, N3 is wrong

7. Role in Urea cycle
Aspartate donates one amino group for the synthesis of urea.
Aspartate forms a connecting link between urea cycle and TCA cycle via oxaloacetate.

8. Role in Purine metabolism
It is utilized in the synthesis of purine at N1 and NH2 at sixth position.
NH₂

9. Role in Pyrimidine metabolism
In pyrimidine synthesis N3,C4,C5 and C6 atoms are synthesized from aspartate. 6 5 4
N1 correct

10. Role in Glucogenic pathway
The carbon skeleton of aspartate can enter the glucogenic pathway as fumarate.
Citrulline + Aspartate Arginine + Fumarate

11. Synthesis of Aspartame
Aspartic acid react with phenylalanine form aspartame which is a artificial sweetener.
It is a mild irritant of the nervous system.
Aspartic acid + phenylalanine Aspartame

12. Help in synthesis of another amino acid
Amino acid like asparagine, arginine, lysine , methionine,threoinine and isoleucine are synthesized from aspartic acid.

13. Function of Aspartic acid
Aspartic acid act as a regulator in synthesis and release of hormone and neurochemicals.
In pituitary glands, aspartic acid stimulates the secretion of following hormones –
Prolactin LH
Growth hormone
Aspartic acid act as a chelating agent. Chelate the minerals to make easier them to assimilate,digest and utilize as calcium, magnesium and potassium aspartate.
Aspartic acid increases the neurological activity.

14. Role in transport of reducing equivalent
NADH that synthesized from glycolysis is present in cytosol.
Mitochondrial membrane is impermeable for the transport of the above .
So a specific shuttle is present over the mitochondrial membrane called malate aspartate shuttle for this transport.

15. Clinical Applications
Chronic Fatigue Syndrome
Exercise recovery and performance .

16. Asparagine It is so named because it is isolated from asparagus.
It was first discovered amino acid.
Vauquelin and Robiquet in 1906 isolated asparagine.
It was shown to be a member of all proteins by Manayath Darmodaran in 1932.

17. ASPARAGINE IS-
Non essential amino acid
Glucogenic amino acid

18. Synthesis From Aspartate
Aspartate reacts with ammonia to form asparagine.

19. Catabolism
Hydrolysis of asparagine-

20. Function Help in development and function of brain.
Important role in the synthesis of ammonia.
Has a role in glycosylation for protein structure and function.
Role in protein biosynthesis.
Ammonia trapping in the brain.

21. Clinical applications of asparagine
Excess intake of asparagine can cause leukemia and lymphomas.
Enzyme asparaginase act as a anticancerous agent use for the treatment of leukemia and lymphomas.
Asparaginase convert excess asparagine into aspartic acid.

22. THANK YOU