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Dermatopathology and molecular genetics

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Presentation on theme: "Dermatopathology and molecular genetics"— Presentation transcript:

1 Dermatopathology and molecular genetics
Reuven Bergman, MD  Journal of the American Academy of Dermatology  Volume 58, Issue 3, Pages (March 2008) DOI: /j.jaad Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Epidermolysis bullosa simplex-Dowling Meara: intraepidermal blister with numerous intracytoplasmic eosinophilic inclusions (arrows) within keratinocytes, reflecting intracytoplasmic keratin aggregations. (Hematoxylin-eosin stain; original magnification: ×1000.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Ectodermic dysplasia/skin fragility syndrome. Intraepidermal blister with few acantholytic keratinocytes. (Hematoxylin-eosin stain; original magnification: ×200.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Atrichia with papular lesions. Scalp biopsy specimen showing replacement of lower two thirds of hair follicle by small epithelial cysts (thin arrow) and irregular epithelial structures (thick arrows). (Hematoxylin-eosin stain; original magnification: ×100.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Striate keratoderma. Partial disadhesion to frank acantholysis of keratinocytes in upper spinous and granular cell layer. (Hematoxylin-eosin stain; original magnification: ×400.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions


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