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Assessing new terminal body and facial hair growth during pregnancy: toward developing a simplified visual scoring system for hirsutism  Yabo Yang, M.D.,

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Presentation on theme: "Assessing new terminal body and facial hair growth during pregnancy: toward developing a simplified visual scoring system for hirsutism  Yabo Yang, M.D.,"— Presentation transcript:

1 Assessing new terminal body and facial hair growth during pregnancy: toward developing a simplified visual scoring system for hirsutism  Yabo Yang, M.D., Ph.D., Yang Han, M.D., Wenjun Wang, M.D., Ph.D., Tao Du, M.D., Ph.D., Yu Li, M.D., Ph.D., Jianping Zhang, M.D., Dongzi Yang, M.D., Ph.D., Xiaomiao Zhao, M.D., Ph.D.  Fertility and Sterility  Volume 105, Issue 2, Pages (February 2016) DOI: /j.fertnstert Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Androgen levels increase as pregnancy progresses. (A) Changes in serum total testosterone level (TT). Serum TT level was measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS).* Compared with the level at pre-pregnancy or at the 5th to 9th week and the 10th to 14th week of gestation, the average testosterone level of pregnant women at the 15th to 20th gestational week increased significantly (P<.001). (B) Changes in the mFG score as pregnancy progresses. ** The mFG score of pregnant women at the 10th to 14th week showed a marked increase compared with that at the 5th to 9th week of gestation (P<.001). (C) The number of cases with new hair growth in various body areas. The body positions with new hair growth were recorded by the subjects themselves and were then confirmed by the interviewer. The order of the facial and body sites that presented with new terminal hair growth was in the following sequence: upper abdomen, lower abdomen, lower back, upper lip, thighs, upper back, chest, upper arm, and chin. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Contributory strength of body positions by ROC analysis in the pregnant women and PCOS cohorts. (A) Areas under the ROC curve of the scores of nine body areas for evaluating hirsutism (total cutoff value was ≥5) in pregnant women. According to the results, the strength of contribution to hirsutism from strong to weak is: upper lip, lower back, thighs, lower abdomen, upper arms, upper back, chest/upper abdomen and chin. The first four positions—upper lip, lower back, thighs, and lower abdomen—were statistically significant. (B) Area under the ROC curve of the summed score of the four body positions (upper lip, lower back, thigh, and lower abdomen) (sFG score) for the evaluation of hirsutism (total cutoff value ≥5) in pregnant women. According to this result, the area under the ROC curve was (95% CI, 0.947–1.001). A cutoff value of 3 had an accuracy of 95.2%, a sensitivity of 96.8% and a specificity of 94.3% in predicting hirsutism. (C) Area under the ROC curve of the simplified mFG score of the first four main body areas (upper lip, lower back, thigh, and lower abdomen), derived from the prospective study of pregnant women for the evaluation of hirsutism (total cutoff value was ≥5) in 1,159 women with PCOS. According to this result, the area under the ROC curve was (95% CI, 0.984–0.994). An sFG score of ≥3 had a sensitivity of 97.6%, a specificity of 96.4% and a positive predictive value of 96.4%. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions


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