1. ReDVA mid-term review meeting Stratos Kokkalis
Dundee 03/06/2015

2. Background BSc, MSc Biomedical Engineering
PhD Biomedical Engineering (November 2014)
University of Dundee
Thesis: Fluid dynamic assessments of spiral flow induced by vascular grafts

3. ReDVA post July 2014 – October 2015 Work packages 4, 5 and 7
ESR seconded from the University of Dundee to Vascular Flow Technologies
Stephen Broderick, Leonard Browne, Nicolas Aristokleous, Conor MacDonald, Craig Dunlop, Graeme Houston

4. ReDVA projects VFT R&D on spiral stent – CAD, flow testing, CFD
VFT R&D on spiral catheters – CAD, flow testing, CFD
VFT validation and verification of new grafts
VFT flow rig
Evaluation of VFT research historical data to update VFT regulatory records
MRI based computational study on haemodialysis fistulas
MRI study on the effect of arm position on vascular shape and haemodynamics

5. Computer aided design of VFT new vascular devices
Spiral stents
Spiral central venous catheters

6. Prototyping of VFT new vascular devices

7. Flow testing of VFT new vascular devices
Flow phantoms
Cadaveric models
Animal models
Phantom
Animal
Cadaver

8. VFT grafts validation and verification
Validation and verification process in industry
Quality regulations – European Medical Device Directive, US Food and Drug Administration, ISO 13485:2003
Product development – new grafts had to come closer to the optimum design
Apply outcomes of my PhD in industry – flow phantoms, imaging, observations on spiral grafts

9. Other experience gained in VFT
Writing qualification reports for industry
Vascular devices commercialisation and marketing
Understanding the difference between academic and industrial approach on problem solving and demands
Computer skills – networks, CAD
Medical devices regulatory processes

10. MRI studies knowledge gained so far
Magnetic resonance imaging techniques
Segmentation of MRI clinical data
Extraction of vascular velocity waveforms
MRI clinical protocol and ethics

11. MRI studies knowledge to be acquired
Patient specific vascular CFD applications
New meshing techniques
CFD simulations with pulsatile flow waveforms
Estimation of advanced WSS parameters

12. Conferences – courses
International Congress of Vascular Access Society 2015
Flow phantoms and imaging – Edinburgh workshop 2015
Public engagement in Dundee Science Festival 2014
MRI conference Dundee 2014
Interventional radiology course 2014
Conference of the Vascular Access Society in Britain and Ireland 2014
Good clinical practice 2014
Great networking opportunities

13. Publications supported by ReDVA
Haemodynamics and peripheral arterial stents, Annals of Biomedical Engineering
Comparison of spiral and conventional arteriovenous grafts using computational methods, Congress of Vascular Access Society, 2015, Barcelona, Spain.
Computational comparison of a spiral and a non-spiral peripheral bypass graft, World Congress of Biomechanics, July, 6-11, 2014, Boston, USA
The effect of position on arterial and venous geometry in the arm: a single case observational study, Congress of Vascular Access Society, 2015, Barcelona, Spain
Re-introducing spiral flow in a vascular access graft using a spiral inducing stent, American Society of Nephrology,2014 Philadelphia, USA
Improving central vein blood flow parameters in central vein catheter dialysis, American Society of Nephrology, 2014, Philadelphia, USA
Great networking opportunities