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Large-Cell Transformation of Mycosis Fungoides Occurring at the Site of Previously Treated Cutaneous B-Cell Lymphoma  Jennifer L. Herrmann, Naveed Sami 

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Presentation on theme: "Large-Cell Transformation of Mycosis Fungoides Occurring at the Site of Previously Treated Cutaneous B-Cell Lymphoma  Jennifer L. Herrmann, Naveed Sami "— Presentation transcript:

1 Large-Cell Transformation of Mycosis Fungoides Occurring at the Site of Previously Treated Cutaneous B-Cell Lymphoma  Jennifer L. Herrmann, Naveed Sami  Clinical Lymphoma, Myeloma and Leukemia  Volume 14, Issue 1, Pages e43-e46 (February 2014) DOI: /j.clml Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 Diffuse Large B-Cell Lymphoma. Clinical Image of Tumor on Patient's Right Knee Clinical Lymphoma, Myeloma and Leukemia  , e43-e46DOI: ( /j.clml ) Copyright © 2014 Elsevier Inc. Terms and Conditions

3 Figure 2 Diffuse Large B-Cell Lymphoma. (A) Dense Dermal Lymphoid Infiltrate (Magnification, ×4); (B) Higher Magnification Showing Variably Sized Lymphoid Cells With Hyperchromatic, Pleomorphic Nuclei and Multiple Mitoses (Magnification, ×40); (C) CD20 Stains Most Larger Cells; (D) Ki-67 Stains Approximately 60% of Total Cells Clinical Lymphoma, Myeloma and Leukemia  , e43-e46DOI: ( /j.clml ) Copyright © 2014 Elsevier Inc. Terms and Conditions

4 Figure 3 Mycosis Fungoides. Superficial Lymphocytic Infiltrate With Atypical Lymphocytes and Prominent Epidermotropism at (A) Magnification ×10, and (B) Magnification ×40, Respectively. Positive TCR-β and TCR-γ Gene Rearrangement Studies Confirmed a Diagnosis of Mycosis Fungoides Abbreviation: TCR = T-cell receptor. Clinical Lymphoma, Myeloma and Leukemia  , e43-e46DOI: ( /j.clml ) Copyright © 2014 Elsevier Inc. Terms and Conditions

5 Figure 4 Large-Cell Transformation of Mycosis Fungoides. (A) Dense Pandermal Lymphoid Infiltrate Without Epidermotropism and a Prominent Grenz Zone (Magnification, ×4); (B) 50% of Large Lymphoid Cells Have Significant Nuclear Pleomorphism and Numerous Mitoses. A Second Population of Smaller Lymphoid Cells are Hyperchromatic and Atypical in Appearance; (C) Lymphoid Cells are CD20-Negative; (D) Lymphoid Cells are CD30+ Clinical Lymphoma, Myeloma and Leukemia  , e43-e46DOI: ( /j.clml ) Copyright © 2014 Elsevier Inc. Terms and Conditions


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