1. Infectious Bronchitis

2. Infectious bronchitis (IB), also called avian infectious bronchitis, is an acute, highly contagious viral respiratory disease of chickens characterized by tracheal rales, coughing, and sneezing.

3. ETIOLOGY Infectious bronchitis virus is a member of the:
Family Coronaviridae
Genus Coronavirus

4. Age of Host Commonly Affected
All ages are susceptible, but the disease is most severe in baby chicks, causing some mortality . As age increases, chickens become more resistant to the nephritogenic effects, oviduct lesions, and mortality due to infection

5. Transmission, Carriers, and Vectors
Infectious bronchitis virus spreads rapidly among chickens in a flock. Susceptible birds placed in a room with infected chickens usually develop signs within 48 hours.
Incubation Period
The incubation period of IB is 18—36 hours, depending on dose and route of inoculation.

6. Signs
The characteristic respiratory signs of IB in chicks are gasping, coughing, sneezing, tracheal rales, and nasal discharge. The chicks appear depressed and may be seen huddled under a heat source.
In laying flocks, declines in egg production and quality are seen in addition to respiratory signs. In addition to production declines, the number of eggs unacceptable for setting is increased; hatchability is reduced; and soft-shelled, misshapen, and rough-shelled eggs are produced.

7. Production curve

8. Internal quality of eggs, as observed when breaking eggs on a flat surface, may be inferior. The albumen may be thin and watery without definite demarcation between the thick and thin albumen of the normal fresh egg.

9. (A) Rough shell. (B) Deformed shell. (C) Soft shell
(A) Rough shell. (B) Deformed shell. (C) Soft shell. Eggs laid by IB-infected hens

10. Contents of two eggs. Normal egg (bottom)
Contents of two eggs. Normal egg (bottom). Egg from chicken exposed to IBV at one day of age (top). Note watery albumen with yolk separated from thick albumen.

11. Gross Lesions
Infected chickens have serous, catarrhal, or caseous exudate in the trachea, nasal passages, and sinuses. Air sacs may appear cloudy or contain a yellow caseous exudate. A caseous plug may be found in the lower trachea or bronchi of chicks that die. Small areas of pneumonia may be observed around the large bronchi.

12. Nephropathic infections produce swollen and pale kidneys with the tubules and ureters often distended with urates.
Histopathology
The mucosa of the trachea of chickens with IB is edematous. There is a loss of cilia, rounding and sloughing of epithelial cells, and minor infiltration of heterophils and lymphocytes within 18 hours of infection.

13. Kidney lesions associated with IB caused by T strain of virus
Kidney lesions associated with IB caused by T strain of virus. Note swollen kidneys with tubules and ureters distended with urates.

14. DIAGNOSIS
Clinical history, lesions, seroconversion or rising IBV antibody titers, IBV antigen detection by a number of antibody-based assays, virus isolation, and, more recently, by detection of IBV RNA.
Differential Diagnosis
Newcastle disease (ND), laryngotracheitis, and infectious coryza

15. INTERVENTION STRATEGIES
Management Procedures
Ideal management includes strict isolation and repopulation with only day-old chicks, following the cleaning and disinfection of the poultry house.

16. Vaccination
No specific treatment exists for IB. Provision of additional heat to eliminate cold stress, elimination of overcrowding, and attempts to maintain feed consumption to prevent weight loss are flock management factors that may
help reduce losses from IB.