Presentation is loading. Please wait.

Presentation is loading. Please wait.

The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report—2014; Focus Theme: Retransplantation 

Similar presentations


Presentation on theme: "The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report—2014; Focus Theme: Retransplantation "— Presentation transcript:

1 The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report—2014; Focus Theme: Retransplantation  Lars H. Lund, MD, Leah B. Edwards, PhD, Anna Y. Kucheryavaya, MS, PhD, Christian Benden, MD, Jason D. Christie, MD, MS, Anne I. Dipchand, MD, FRCPC, Fabienne Dobbels, PhD, Samuel B. Goldfarb, MD, Bronwyn J. Levvey, RN, Bruno Meiser, MD, Roger D. Yusen, MD, MPH, Josef Stehlik, MD, MPH  The Journal of Heart and Lung Transplantation  Volume 33, Issue 10, Pages (October 2014) DOI: /j.healun Copyright © Terms and Conditions

2 Figure 1  Number of heart transplants (all recipient ages) by year (1982–2012) and geographic region. Includes heart transplants reported to the International Society for Heart and Lung Transplantation Transplant Registry (an estimated 66% of all heart transplants worldwide) and may not fully mirror numbers or changes worldwide. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

3 Figure 2  Average annual heart transplant volume by center for all recipient ages (transplants: 2006–June 2013). Columns show the number of centers performing the number of transplants on the x-axis (e.g., 114 centers perform 10–19 heart transplants per year). The curve shows the percentage of all transplants performed at centers performing the number of transplants listed on the x-axis (e.g., 38% of all heart transplants are performed by the 114 centers that each performed 10–19 heart transplants per year). The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

4 Figure 3  Recipient (adults) and donor age matching for primary transplants and retransplants (transplants: 2006–June 2013). The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

5 Figure 4 Recipient age distribution (adult and pediatric) by era.
The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

6 Figure 5  Diagnosis by recipient age group in adult heart transplants (2006–June 2013). For some retransplants (Retx) diagnosis other than retransplant is reported, so the total percentage of retransplants performed may be greater. CAD, coronary artery disease. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

7 Figure 6  Time between previous and current transplant for adult heart transplants (2006–June 2013). The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

8 Figure 7  Diagnosis (indication for retransplantation) by location for adult heart retransplants (2006–June 2013). CAV, coronary allograft vasculopathy. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

9 Figure 8  Panel reactive antibody (PRA) by type of transplant in adult heart primary transplants and retransplants (2006–June 2013). The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

10 Figure 9  Durable and temporary mechanical circulatory support use by type of transplant in adult heart primary transplants and retransplants (2006–June 2013). ECMO, extracorporeal membrane oxygenation; LVAD, left ventricular assist device; RVAD, right ventricular assist device; TAH, total artificial heart. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

11 Figure 10  Kaplan-Meier long-term survival by era in adult heart transplants. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

12 Figure 11  Kaplan-Meier (A) 1-year survival, (B) long-term survival, and (C) long-term survival conditional on survival to 1 year by diagnosis for adult heart transplants (1982–June 2012). CAD, coronary artery disease. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

13 Figure 12  Kaplan-Meier (A) 1-year survival, (B) long-term survival, and (C) long-term survival conditional on survival to 1 year by diagnosis (indication for retransplantation) for adult heart retransplants (1982–June 2012). CAV, cardiac allograft vasculopathy. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

14 Figure 13  Survival according to transplant type and pre-transplant ventricular assist device (VAD) and inotrope use in adult heart primary transplants and retransplants (1999–June 2012). LVAD, left ventricular assist device. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

15 Figure 14  Causes of death (1994–June 2013) by primary vs different indications for retransplantation in adult heart primary transplants and retransplants. CAV, cardiac allograft vasculopathy; CMV, cytomegalovirus; PTLD, post-transplant lymphoproliferative disorder. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

16 Figure 15  Induction immunosuppression by location and type of transplant in adult heart primary transplants and retransplants (2005–June 2013). ALG, anti-lymphocyte globulin; ATG, anti-thymocyte globulin; IL-2R, interleukin-2 receptor. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

17 Figure 16  Maintenance immunosuppression at 1-year and 5-year follow-up by location and type of transplant for adult heart primary transplants and retransplants (2008–June 2013). MMF, mycophenolate mofetil, MPA, mycophenolic acid. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

18 Figure 17  Freedom from hospitalization for rejection by era for adult heart transplants (1994–June 2012). The sample size does not allow separation into primary transplants and retransplants. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions

19 Figure 18  Categorical risk factors for 1-year post-transplant mortality in multivariate analysis for adult heart transplants (2007–June 2012). BiVAD, biventricular assist device; CAD, coronary artery disease; CI, confidence interval; CM, cardiomyopathy; ECMO, extracorporal membrane oxygenation; F, female; HR, hazard ratio; IV, intravenous; LCL, lower confidence limit; LVAD, left ventricular assist device; M, male; RVAD, right ventricular assist device; rx, medication; UCL, upper confidence limit. The Journal of Heart and Lung Transplantation  , DOI: ( /j.healun ) Copyright © Terms and Conditions


Download ppt "The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report—2014; Focus Theme: Retransplantation "

Similar presentations


Ads by Google