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Figure S1 p = 0.006 NSCLC SCLC TP53 allelic frequency (%)
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Figure S2 VSC-4 A. B. Days from diagnosis: 11 119 447 474 544 569 572
579 586 615 625 652 Cisplatin + etoposide PCI Carboplatin + etoposide Paclitaxel Radiographic progression Radiographic progression CT scan Radiographic progression CT scan MRI scan Patient Expired CT scan Day 499 Day 569 Day 625 Day 625 B.
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Carboplatin + etoposide
Figure S3 VSC-12 Days from diagnosis: 57 141 176 233 274 279 372 RT RT Carboplatin + etoposide CT scan Radiographic progression PET scan Patient expired CT scan CT scan B. Day 0 Day 51 Day 232 Day 274
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Radiographic progression
Figure S4 VSC-25 43 67 86 114 163 282 366 408 424 541 Days from diagnosis: RT Cisplatin + etoposide Prexasertib CT scan Radiographic progression CT scan Last follow up date Day 50 Day 408 B.
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Carboplatin + etoposide
Figure S5 VSC-27 Days from diagnosis: 4 92 150 188 235 237 274 310 318 329 342 352 Carboplatin + etoposide Paclitaxel CT scan Radiographic progression CT scan Radiographic progression CT scan Last follow up date Day 0 Day 193 Day 235 Day 329 B.
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Carboplatin + etoposide
Figure S6 VSC-1 Days from diagnosis: 82 161 285 376 397 446 518 553 593 698 Carboplatin + etoposide Nivolumab Radiographic progression CT scan Active surveillance Radiographic progression Patient Expired CT scan CT scan Day 376 Day 446 Day 518 B.
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Carboplatin + etoposide Carboplatin + etoposide
Figure S7 VSC-7 5 47 RT 96 278 327 348 378 500 545 Days from diagnosis: Carboplatin + etoposide PCI Carboplatin + etoposide Radiographic progression Last follow up date CT scan CT scan CT scan CT scan Radiographic progression CT scan CT scan Day 0 Day 47 Day 96 Day 159 Day 278 Day 292 B.
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Carboplatin + etoposide
Figure S8 VSC-19 Days from diagnosis: 10 56 95 119 142 228 262 352 Carboplatin + etoposide PCI RT Last follow up date CT scan CT scan CT scan Day 0 Day 53 Day 290 B.
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Figure S9 VSC-28 A. B. 41 98 132 223 Days from diagnosis: RT
Cisplatin + etoposide CT scan Last follow up date CT scan B. Day 0 Day 223
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Carboplatin + etoposide
Figure S10 VSC-18 Days from diagnosis: 39 63 82 92 105 145 185 187 194 228 Carboplatin + etoposide Nivolumab P Radiographic progression CT scan Radiographic progression CT scan Last follow up date CT scan Day 26 Day 82 Day 185 B. C. Genomic alterations Tissue NGS cfDNA NGS TP53 A161T PTEN V343fs*2 MYC amplification PIK3CA amplification RB1 splice site G>C RB1 deletion SOX2 amplification N/A NTRK3 R721H PALB2 S254fs*3 LRP1B loss exons 12-75
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Figure S11 A. B. C. D. cfDNA end repair P7 P5 READ 1 READ 2
Capture probe primer extension A. B. C. Genomic library D. Anchor ligation Adaptor addition QC
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Figure S12 A. B. C.
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Figure S13
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