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Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World.

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Presentation on theme: "Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World."— Presentation transcript:

1 Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138: DOI: / Fig. 1. The schedule for dose adjustment. Lenalidomide (Len) was started on a minimum dose and gradually increased to the highest dose during days 1-21. © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

2 Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138: DOI: / Fig. 2.a The median TTP was 11.8 months (range ). b The median OS was 39.2 months (range 26.6 to not determined). Lenalidomide was started on a minimum dose and gradually increased to the highest dose during days 1-14. © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

3 Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138: DOI: / Fig. 3. Correlation between cumulative doses and best response. The median cumulative dose was 1,097.5 mg (range 80-9,870). The correlation coefficient between cumulative dose and best response was (p = 0.324). CR, complete response; VGPR, very good partial response; PR, partial response; SD, stable disease; PD, progressive disease. © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

4 Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138: DOI: / Table 1. Patient characteristics © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

5 Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138: DOI: / Table 2. Comparison of starting and continued doses © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

6 Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138: DOI: / Table 3. Reasons for reduction © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

7 Realistic Lenalidomide Dose Adjustment Strategy for Transplant-Ineligible Elderly Patients with Relapsed/Refractory Multiple Myeloma: Japanese Real-World Experience Acta Haematol 2017;138: DOI: / Table 4. Response rate © 2017 The Author(s) Published by S. Karger AG, Basel - CC BY-NC-ND 4.0

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