1. Chapter 11 RES 219 Pharmacology
Corticosteroids
Chapter 11
RES 219
Pharmacology

2. Corticosteroids Clinical indications What is a corticosteroid?
HPA – Hypothalamic Pituitary Adrenal axis
Diurnal rhythm
HPA/adrenal suppression

3. Airway inflammation What causes inflammation? Terms: Immune system
Antigens
Immunoglobulins (IgE)
Mast cells
Histamine
Bronchospasm
Inflammation

4. Corticosteroids
Mechanism of action
Prevent “airway remodeling”

5. Aerosolized Corticosteroid Agents
beclomethasone (QVAR)
fluticasone (Flovent/Arnuity)
budesonide (Pulmicort)
ciclesonide (Alvesco)
flunisolide (Aerospan)
mometasone (Asmanex)

6. Combination (Steroid/LABA)
Advair (fluticasone/salmeterol)
Symbicort (budesonide/formoterol)
Dulera (mometasone/formoterol)
Breo (fluticasone/vilanterol)

7. Systemic steroids Prednisone Prednisolone
Methylprednisolone (Solu-Medrol)

8. Adverse Effects of Corticosteroids
Aerosol vs systemic
Inhaled (local/topical) effects
Systemic effects