1. NIHR University College London Hospitals and UCL Biomedical Research Centre
Professor Bryan Williams
Chair of Medicine UCL
Director; NIHR UCLH/UCL Biomedical Research Centre,
Director; Research & Development UCL Hospitals
University College London

2. Our vision In five years our BRC partnership will be a world leading
Professional Translational
Research Organisation
Accelerating patient access to medical innovation
VISION

3. World class Discovery Science1
NIHR/RAND metrics –
biggest aggregation of biomedical
science in Europe
World class Discovery Science
UK REF 2014
research power and research impact 1
World ranking for preclinical
and clinical science
(Times Higher 2015) 4
Over 700 BRC publications 2015/16,
rising from 200 in 2012
(current BRC H-Index 96, 55,000 citations)
Francis Crick Institute founding partner
and its natural translational partner
VISION

4. University / NHS Partnership
Alignment of UCL Research Strength
with UCLH Clinical Excellence
World Class
discovery science
UCLH is a research hospital
A Strong
University / NHS Partnership
Joint capital clinical / research investment
in next 5 years
£1.5bn
Unparalleled access to patients
with rare and complex diseases
VISION

5. 20:20 VISION World Class discovery science
Largest innovative/complex early phase
research program in Europe
3-fold increase in phase I / II trials
since 2012; and growing exponentially
A Strong
University / NHS Partnership
Leading in UK: MRC early phase
trials awards (DPFS) – 25% of all awards
Explicit Focus
on Experimental Medicine and Translation
Leading in Europe: UCL top for
Horizon 20:20 awards in Health
20:20
VISION

6. 1 VISION Harnessing technological innovation
Transforming drug discovery,
target identification and validation
Computer science
Healthcare Engineering and Imaging
(REF2014)
High Through-Put Platforms
(genomic, omic, imaging)
with Patient Data linked at scale
UCL Farr Institute – Data Science
(Only BRC-affiliated University with a Farr Institute)
Partnership with the Alan Turing Institute,
Google Deep Mind, eMedLab and EBI
eMedLab – high performance computing cluster for genomic, imaging and patient data
VISION

7. 3 £100m £100m £600m VISION High Through-Put Platforms
(genomic, omic, imaging)
with Patient Data linked at scale
TREACC – Professional support for
Translational Research and commercialisation
£100m
Syncona investment into UCL in past year
Enterprise culture Industry Partnerships
Creating Value
UCL Technology and Apollo Start-up funds
£100m
Leveraged in current BRC in 5 years (£8:1)
£600m
Major Pharma embedded industry partners
for drug discovery (Takeda, Eisai, and GSK) 3
VISION

8. VISION High Through-Put Platforms with Patient Data linked at scale
(genomic, omic, imaging)
with Patient Data linked at scale
Enterprise culture Industry Partnerships
Creating Value
The BRC Experimental Medicine Academy
BRC supported PhD students
increasing from 101 (2012) to 315 (2015)
>90% conversion to fellowships
Building Resilience Training the next generation of Experimental Medicine Leaders
VISION

9. THEMES Existing Themes New Themes Cross-cutting Themes 1 3
NIHR University College London Hospitals / UCL Biomedical Research Centre
BRC Director
Bryan Williams
Existing
Themes
Neuroscience
Nicholas Wood
Dementia
Martin Rossor
Cancer
David Linch
Immunity,
Inflammation &
Immunotherapeutics
Emma Morris
Cardiovascular
Aroon Hingorani 1 3
Robert Howard
Mental Health
Anne Schilder
Deafness and
Hearing
New
Themes
Stefano Fedele
Oral Health
& Disease
Sharon Peacock
Infection &
Antimicrobial
Resistance
Rachel Batterham
Obesity
Cross-cutting
Themes
Health Care Engineering and Imaging
Health Care Informatics, Genomics, “-omics” & Data Science
BRC Education and Training Program – The BRC Academy
Translational Research and Enterprise Accelerator (TREACC)
Public Involvement, Engagement and Communications
UCL Therapeutic Innovation Network
Bart Vanhaesebroeck
Sebastian Ourselin
Harry Hemingway
Geraint Rees
David Lomas
Simon Denegri
THEMES

10. UCLH UCL BRC RESEARCH ECOSYSTEM Global National Patients Pan UCL
NIHR UCLH CRF
Sir Francis Crick Institute
Farr Institute for Informatics
Alan Turing Institute
UCL Computer Science
Google
Deep Mind
UCL Partners Academic Health Sciences Centre
UCL
7 MRC Centres
Wolfson and Alzheimer’s UK Drug Discovery Institutes
BRC Academy in Experimental Medicine
Bloomsbury Research Institute
Cancer Research UK Centre
Embedded Industry Partnerships
Discovery Science
Global
Academic
Industry
Partnerships
Clinical Translation
Genomics Proteomics Metabolomics
Patient & Public Involvement & Engagement
Patients
National
Pan-NIHR
Bioresource
TRCs
NIHR HIC
Imaging & Health Care Engineering
Translational Research & Enterprise Accelerator
Health Care Informatics & Data Science
Pan UCL
AHSC
GOSH BRC
Moorfields BRC
Therapeutic Innovation Networks
BRC RESEARCH
ECOSYSTEM

11. World Class Science Transforming Patients’ Lives
1000 new phase I/II Trials
Accelerating Patient Access
1000 new phase I/II Trials
Accelerating Patient Access
Vanguard treatments for Cancer
Proton Beam
National Centre for Cancer Immunotherapy
Vanguard treatments for Cancer
Proton Beam
National Centre for Cancer Immunotherapy
Genomics / omics platforms with patient data linkage at scale
Innovating and Repurposing
Applied engineering for diagnostics and imaging
precision medicine
Create 30 new companies
new treatments for many previously intractable diseases
Create 30 new companies
new treatments for many previously intractable diseases
Innovative treatments for dementia and neurological diseases
Identifying and Targeting the disease pro-drome
Innovative treatments for dementia and neurological diseases
Identifying and Targeting the disease pro-drome
Embedded industry partnerships - drug discovery
the human as the experimental model
Embedded industry partnerships - drug discovery
the human as the experimental model
Disruptive innovation in Cellular and Gene therapies
the leading centre in Europe
Disruptive innovation in Cellular and Gene therapies
the leading centre in Europe
Applied engineering for diagnostics and imaging
precision medicine
Applied engineering for diagnostics and imaging
precision medicine
Inward investment
We will leverage £1bn
Creating Health and Wealth
Inward investment
We will leverage £1bn
Creating Health and Wealth
WHAT WE
WILL DELIVER