1. FASD in San Diego, Moscow, and Helsinki Sarah Mattson, PI
Collaborative Initiative on Fetal Alcohol Spectrum Disorders
PI Progress Meeting
February 2006

2. Collaborators San Diego Moscow Helsinki Sarah Mattson Edward Riley
Galina Marintcheva
Valentina Konovalova
Tatiana Riazanova
Helsinki
Ilona Autti-Rämö
Marit Korkman
Åse Fagerlund

3. Summary of Progress Dysmorphology = 299+ cases
74 SD; 140 Helsinki; 85+ Moscow
3D Facial Imaging = 193 cases
70 SD; 123 Helsinki
Neurobehavioral = 248 cases
76 SD; 136 Helsinki; 34 Moscow
Imaging = 50 cases
30 SD (MRI); 20 Helsinki (MRS)
Updated 1/06

4. Demographic Information
San Diego
Helsinki
Moscow
FASD
CON
CONT N 37 36 76 40 30 27 7
Sex (% Female)
43.2
44.4
59.2
55.0
53.3
28.6
Ethnicity (% White)
64.9
72.2
100
Race (% Hispanic)
18.9
19.4
N/A
SES (M +/- SD)
46.5 +/- 12.9
50.9 +/- 11.9
Age (M +/- SD)
13.1 +/- 3.0
12.1 +/- 2.82
13.3 +/- 3.6
13.5 +/- 3.6
13.3 +/- 2.9
15.3 +/- 1.6
15.3 +/- 1.1
FSIQ (M +/- SD)
91.1 +/- 12.8
96.7 +/- 18.6
74.1 +/- 10.4
79.0 +/-9.4
Updated 1/06

5. Edinburgh
Score closer to 1.0 = “more” right handed. Scores closer to -1 = more left handed.
Updated 1/06

6. General Intellectual Functioning
Leiter Brief IQ
WISC-III
Raven’s SPM

7. Overall Mean IQ Score Comparison
Updated 1/06
Just SD

8. Individual IQ Score Comparison
Correlation is .53
Updated 1/06
Just SD

9. Questionnaires & Rating Scales
Disruptive Behavior Disorder Rating Scale (Pelham)
Sluggish Cognitive Tempo (McBurnett & Pfiffner)
Child Behavior Checklist, Teacher Rating Form, Youth Self Report (Achenbach)
Pictorial Depression Scale

10. DBD Parent-Teacher Rating Scale
San Diego
Helsinki
FASD
CON
CONT
% ADHD-
Inattentive Subtype
64.9
2.9
36.0
26.7
11.8
H/I Subtype
37.8
0.0
32.0
6.7
% ODD
48.7
16.0
20.0
% CD
24.3
4.0
5.9
Updated 1/06

11. Sluggish Cognitive Tempo
Updated 1/06

12. Pictorial Depression Scale
Add picture

13. Pictorial Depression Scale
N >10 (SD)
FASD = 14 (37.8%)
CON = 9 (25%)
A cut off of >10 indicates clinical significance
Updated 1/06
Cutoffs are just SD
14/37 (37.8%) FASD >10
9/36 (25%) Controls >10

14. Nonverbal Learning & Memory
Virtual Water Maze
CANTAB
Pattern and Spatial Recognition
Spatial Span
Spatial Working Memory

15. VWM Time Spent in NE Quadrant
Total N
FASD = 72
CON = 53
CONT = 20
Updated 1/06
These are Means from SD, Finland, Moscow
Total N = 72 FASD, 53 CON, and 20 CONTRAST
San Diego, Helsinki, & Moscow

16. VWM Total Latency to Find Platform
Total N
FASD = 72
CON = 53
CONT = 20
Updated 1/06
San Diego, Helsinki, & Moscow

17. VWM Path Length (Relative to Pool Diameter)
Total N
FASD = 72
CON = 53
CONT = 20
Updated 1/06
San Diego, Helsinki, & Moscow

18. CANTAB Recognition Memory
Updated 1/06
San Diego & Moscow
San Diego & Moscow

19. CANTAB Spatial Span
New 1/06
SD & Moscow
San Diego & Moscow

20. CANTAB Spatial Working Memory
New 1/06
SD and Moscow
San Diego & Moscow

21. Attention
Attention Sustained (Leiter)
NES-3

22. Leiter Attention Sustained
Updated 1/06
Just SD

23. NES-3 CPT Single Following Repeating Cat Wolf followed by a Cat
e.g., cat-cat, pig-pig
NES#: D/c testing: Total (Russia and SD) = 3 in FASD (2 Russia, 1 SD), 1 in control (1 Russia).
SM-I don’t know where you got these numbers so I left them alone.

24. CPT - Following
Updated 1/06
Just SD
Reaction Time
Accuracy
Errors

25. Executive Function Verbal Fluency (DKEFS) Trail Making (DKEFS)
Progressive Planning Test (Kodituwakku)
Reversal Learning (Kodituwakku)

26. Verbal Fluency Updated 1/06
Letter - Category is scaled score for difference. Score < 10 = letter < Category
Just SD

27. Trail Making
Updated 1/06
Just SD

28. Progressive Planning Test (Counts)
New 1/06
Just SD
1st Trial = cards correct on 1st trial
All Trials = cards correct no matter if trial 1, 2, or 3
Level 1 = cards correct on items 1-4, no matter what trial
Level 2 = cards correct on items 5-8, no matter what trial
(Level 2 cards have 1 more manipulation, i.e., an extra bead, than Level 1 cards)

29. Reversal Learning Total N FASD = 43 CON = 40 San Diego & Moscow
Updated 1/06
San Diego & Moscow
1 SD subject was discontinued after the 1st reversal, because they did not get it after >100 trials.
San Diego & Moscow

30. Current Projects
McGee, C.L., Vaurio, L.E., Mattson, S.N., Riley, E.P., Marintcheva, G., Konovalova, V. (2006). Wisc subtest performance in Russian children with fetal alcohol syndrome and IQ-matched controls. Submitted to RSA 2006.
Vaurio, L.E., McGee, C.L., Kane, A. Riley, E.P., Marintcheva, G., Konovalova, V., and Mattson, S.N. Relationship of IQ and WCST performance in children with fetal alcohol syndrome. Manuscript in preparation.

31. Plans for 2006 Continue collecting data: San Diego & Moscow
Score & verify protocols: All sites
Enter data into neuro input tool
Submit Abstracts to RSA & ISBRA