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Effect of erythropoietin on liver regeneration in an experimental model of partial hepatectomy  Mesut Gul, Mustafa Cömert, Güldeniz Karadeniz Çakmak,

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Presentation on theme: "Effect of erythropoietin on liver regeneration in an experimental model of partial hepatectomy  Mesut Gul, Mustafa Cömert, Güldeniz Karadeniz Çakmak,"— Presentation transcript:

1 Effect of erythropoietin on liver regeneration in an experimental model of partial hepatectomy 
Mesut Gul, Mustafa Cömert, Güldeniz Karadeniz Çakmak, Gurkan Kertis, Ebru Ugurbas, Muzaffer Onder Oner  International Journal of Surgery  Volume 11, Issue 1, Pages (January 2013) DOI: /j.ijsu Copyright © 2012 Surgical Associates Ltd Terms and Conditions

2 Fig. 1 RLW was determined to be higher in the EPO-treated groups in all three time periods (*p < 0.05). International Journal of Surgery  , 59-63DOI: ( /j.ijsu ) Copyright © 2012 Surgical Associates Ltd Terms and Conditions

3 Fig. 2 A, B, C. Mitosis index was higher at 48 and 72 h in the EPO-treated groups (**p < 0.001) (A), appearance of mitotic activity at 48 h after liver resection (H&E 100x) (B), and increase in mitotic activity 48 h after EPO treatment (H&E 200x) (C). Blue arrows indicate increased mitotic activity. International Journal of Surgery  , 59-63DOI: ( /j.ijsu ) Copyright © 2012 Surgical Associates Ltd Terms and Conditions

4 Fig. 3 A, B, C. Double nuclei cell number was higher at 72 h in the EPO-treated groups (*p = 0.018) (A), appearance of double nuclei cells at 72 h after liver resection (H&E 100x) (B), increase in double nuclei cell number 72 h after EPO treatment (H&E 200x) (C). Blue arrows indicate increased double nuclei cell number. International Journal of Surgery  , 59-63DOI: ( /j.ijsu ) Copyright © 2012 Surgical Associates Ltd Terms and Conditions

5 Fig. 4 A, B, C. Calculated PCNA staining ratios were higher at 48 h in the EPO-treated group (**p < 0.001) (A), appearance of PCNA stained cells at 48 h after liver resection (H&E 100x) (B), increase in PCNA staining ratios 48 h after EPO treatment (H&E 400x) (C). International Journal of Surgery  , 59-63DOI: ( /j.ijsu ) Copyright © 2012 Surgical Associates Ltd Terms and Conditions


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