1. Chapter 6 Bones &Skeletal Tissues
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2. Cartilage Characteristics Avascular connective tissue
Fibers of cartilage are embedded in a firm gel
Has the flexibility of firm plastic
No canal system or blood vessels
Chondrocytes receive oxygen and nutrients by diffusion
Perichondrium—fibrous covering of the cartilage
Cartilage types differ because of the amount of matrix present and the amounts of elastic and collagenous fibers
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3. Cartilage Types of cartilage Hyaline cartilage Most common type
Covers the articular surfaces of bones
Forms the costal cartilages, cartilage rings in the trachea, bronchi of the lungs, and the tip of the nose
Forms from specialized cells in centers of chondrification, which secrete matrix material
Chondrocytes are isolated into lacunae
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4. Cartilage Types of cartilage (cont.) Elastic cartilage Fibro cartilage
Forms external ear, epiglottis, and eustachian tubes
Large number of elastic fibers confers elasticity and resiliency
Fibro cartilage
Occurs in symphysis pubis and intervertebral disks
Small quantities of matrix and abundant fibrous elements
Strong and rigid
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5. Cartilage Histophysiology of cartilage
Gristle-like nature permits cartilage to sustain great weight or serve as a shock absorber
Strong yet pliable support structure
Permits growth in length of long bones
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6. Cartilage Growth of cartilage Interstitial or endogenous growth
Cartilage cells divide and secrete additional matrix
Seen during childhood and early adolescence while cartilage is still soft and capable of expansion from within
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7. Cartilage Growth of cartilage (cont.) Appositional or exogenous growth
Chondrocytes in the deep layer of the perichondrium divide and secrete matrix
New matrix is deposited on the surface, increasing its size
Unusual in early childhood but, once initiated, continues throughout life
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8. Functions of Bone
Support—bones form the framework of the body and contribute to the shape, alignment, and positioning of the body parts
Protection—bony “boxes” protect the delicate structures they enclose
Movement—bones with their joints constitute levers that move as muscles contract
Mineral storage—bones are the major reservoir for calcium, phosphorus, and other minerals
Hematopoiesis—blood cell formation is carried out by myeloid tissue
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9. Types of Bones
Structurally, there are four types of bones (Figure 7-1):
Long bones
Short bones
Flat bones
Irregular bones
Bones serve various needs, and their size, shape, and appearance will vary to meet those needs
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10. Types of Bones Parts of a long bone (Figure 7-2) Diaphysis
Main shaft of long bone
Hollow, cylindrical shape and thick, compact bone
Function is to provide strong support without cumbersome weight
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11. Types of Bones Parts of a long bone (cont.) Epiphyses
Both ends of a long bone, made of cancellous bone filled with marrow
Bulbous shape
Function is to provide attachments for muscles and give stability to joints
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12. Types of Bones Parts of a long bone (cont.) Articular cartilage
Layer of hyaline cartilage that covers the articular surface of epiphyses
Function is to cushion jolts and blows
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13. Types of Bones Parts of a long bone (cont.) Periosteum
Dense, white, fibrous membrane that covers bone
Attaches tendons firmly to bones
Contains cells that form and destroy bone
Contains blood vessels important in growth and repair
Contains blood vessels that send branches into bone
Essential for bone cell survival and bone formation
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14. Types of Bones Parts of a long bone (cont.)
Medullary (or marrow) cavity
Tubelike, hollow space in diaphysis
Filled with yellow marrow in adult
Endosteum—thin epithelial membrane that lines medullary cavity
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15. Types of Bones Short, flat, and irregular bones
Inner portion is cancellous bone, covered on the outside with compact bone
Spaces inside cancellous bone of a few irregular and flat bones are filled with red marrow
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16. Types of Bones
Bones vary in their proportions of compact and cancellous (spongy) bone; compact bone is dense and solid in appearance, whereas cancellous bone is characterized by open space partially filled with needle-like structures
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17. Bone Marrow
Two types of marrow are present during a person’s lifetime:
Red marrow
Found in virtually all bones in an infant’s or child’s body
Functions to produce red blood cells
Yellow marrow
As an individual ages, red marrow is replaced by yellow marrow
Marrow cells become saturated with fat and are no longer active in blood cell production
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18. Bone Marrow
The main bones in an adult that still contain red marrow include the ribs, bodies of the vertebrae, the humerus, the pelvis, and the femur
Yellow marrow can alter to red marrow during times of decreased blood supply, such as with anemia, exposure to radiation, and certain diseases
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19. Bone Marrow
Specialized type of soft, diffuse connective tissue; called myeloid tissue
Site for the production of blood cells
Found in medullary cavities of long bones and in the spaces of spongy bone
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20. Bone Tissue Extracellular components are hard and calcified
Rigidity of bone allows it to serve its supportive and protective functions
Tensile strength is nearly equal to cast iron at less than one third the weight
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21. Bone Tissue Composition of bone matrix (cont.)
Measuring bone mineral density
Organic matrix
Composite of collagenous fibers and an amorphous mixture of protein and polysaccharides called ground substance
Ground substance is secreted by connective tissue cells
Adds to overall strength of bone and gives some degree of resilience to the bone
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22. Microscopic Structure of the Bone (Figure 7-3)
Compact bone
Contains many cylinder-shaped structural units called osteons, or Haversian systems
Osteons surround canals that run lengthwise through bone and are connected by transverse Volkmann’s canals
Living bone cells are located in these units, which constitute the structural framework of compact bone
Osteons permit delivery of nutrients and removal of waste products
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23. Microscopic Structure of the Bone
Compact bone (cont.)
Four types of structures make up each osteon:
Lamella—concentric, cylinder-shaped layers of calcified matrix
Lacunae—small spaces containing tissue fluid in which bone cells are located between hard layers of the lamella
Canaliculi—ultrasmall canals radiating in all directions from the lacunae and connecting them to each other and to the Haversian canal
Haversian canal—extends lengthwise through the center of each osteon and contains blood vessels and lymphatic vessels
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24. Microscopic Structure of the Bone
Blood supply
Bone cells are metabolically active and need a blood supply, which comes from the bone marrow in the internal medullary cavity of cancellous bone
Compact bone, in addition to bone marrow and blood vessels from the periosteum, penetrate bone and then, by way of Volkmann’s canals, connect with vessels in the Haversian canals
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25. Microscopic Structure of the Bone
Types of bone cells
Osteoblasts
Bone-forming cells found in all bone surfaces
Small cells synthesize and secrete osteoid, an important part of the ground substance
Collagen fibrils line up in osteoid and serve as a framework for the deposition of calcium and phosphate
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26. Microscopic Structure of the Bone
Types of bone cells (cont.)
Osteoclasts (Figure 7-5)
Giant multinucleate cells
Responsible for the active erosion of bone minerals
Contain large numbers of mitochondria and lysosomes
Osteocytes—mature, nondividing osteoblast surrounded by matrix, lying within lacunae (Figure 7-6)
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27. Microscopic Structure of the Bone
Cancellous bones (Spongy bone 7-4)
No osteons in cancellous bone; instead, it has trabeculae
Nutrients are delivered and waste products removed by diffusion through tiny canaliculi
Bony spicules are arranged along lines of stress, enhancing the bone’s strength
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28. Bone Tissue Composition of bone matrix Inorganic salts
Hydroxyapatite—highly specialized chemical crystals of calcium and phosphate contribute to bone hardness
Slender, needle-like crystals are oriented to most effectively resist stress and mechanical deformation
Magnesium and sodium are also found in bone
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29. Development of Bone
Osteogenesis—development of bone from small cartilage model to an adult bone
Intramembranous ossification
Occurs within a connective tissue membrane
Flat bones begin when groups of cells differentiate into osteoblasts
Osteoblasts are clustered together in centers of ossification
Osteoblasts secrete matrix material and collagenous fibrils
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30. Development of Bone Intramembranous ossification (cont.)
Large amounts of ground substance accumulate around each osteoblast
Collagenous fibers become embedded in the ground substance and constitute the bone matrix
Bone matrix calcifies when calcium salts are deposited
Trabeculae appear and join in a network to form spongy bone
Apposition growth occurs by adding of osseous tissue
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31. Development of Bone Endochondral ossification (Figure 7-8)
Most bones begin as a cartilage model, with bone formation spreading essentially from the center to the ends
Periosteum develops and enlarges, producing a collar of bone
Primary ossification center forms
Blood vessel enters the cartilage model at the midpoint of the diaphysis
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32. Development of Bone Endochondral ossification (cont.)
Bone grows in length as endochondral ossification progresses from the diaphysis toward each epiphysis
Secondary ossification centers appear in the epiphysis, and bone growth proceeds toward the diaphysis
Epiphyseal plate remains between diaphysis and each epiphysis until bone growth in length is complete (Figure 7-10)
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33. Development of Bone Endochondral ossification (cont.)
Epiphyseal plate is composed of four layers (Figure 7-9):
“Resting” cartilage cells—point of attachment joining the epiphysis to the shaft
Zone of proliferation—cartilage cells undergoing active mitosis, causing the layer to thicken and the plate to increase in length
Zone of hypertrophy—older, enlarged cells undergoing degenerative changes associated with calcium deposition
Zone of calcification—dead or dying cartilage cells undergoing rapid calcification
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34. Bone Growth and Resorption (Figures 7-11 and 7-12)
Bones grow in diameter by the combined action of osteoclasts and osteoblasts
Osteoclasts enlarge the diameter of the medullary cavity
Osteoblasts from the periosteum build new bone around the outside of the bone
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35. Regulation of Blood Calcium Levels
Skeletal system serves as a storehouse for about 98% of body calcium reserves
Helps maintain constancy of blood calcium levels
Calcium is mobilized and moves into and out of blood during bone remodeling
During bone formation, osteoblasts remove calcium from blood and lower circulating levels
During breakdown of bone, osteoclasts release calcium into blood and increase circulating levels
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36. Regulation of Blood Calcium Levels
Skeletal system (cont.)
Homeostasis of calcium ion concentration essential for the following:
Bone formation, remodeling, and repair
Blood clotting
Transmission of nerve impulses
Maintenance of skeletal and cardiac muscle contraction
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37. Regulation of Blood Calcium Levels
Mechanisms of calcium homeostasis
Parathyroid hormone
Primary regulator of calcium homeostasis
Stimulates osteoclasts to initiate breakdown of bone matrix and increase blood calcium levels
Increases renal absorption of calcium from urine
Stimulates vitamin D synthesis
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38. Regulation of Blood Calcium Levels
Mechanisms of calcium homeostasis (cont.)
Calcitonin
Protein hormone produced in the thyroid gland
Produced in response to high blood calcium levels
Stimulates bone deposition by osteoblasts
Inhibits osteoclast activity
Far less important in homeostasis of blood calcium levels than parathyroid hormone
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39. Repair of Bone Fractures
Fracture—break in the continuity of a bone
Fracture healing (Figure 7-13)
Fracture tears and destroys blood vessels that carry nutrients to osteocytes
Vascular damage initiates repair sequence
Callus—specialized repair tissue that binds the broken ends of the fracture together
Fracture hematoma—blood clot occurring immediately after the fracture, is then resorbed and replaced by callus
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40. Cycle of Life: Skeletal Tissues
Skeleton fully ossified by mid-twenties
Soft tissue may continue to grow—ossifies more slowly
Adults—changes occur from specific conditions
Increased density and strength from exercise
Decreased density and strength from pregnancy, nutritional deficiencies, and illness
Advanced adulthood—apparent degeneration
Hard bone matrix replaced by softer connective tissue
Exercise can counteract degeneration
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