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Current sequencing technology makes microhaplotypes a powerful new type of genetic marker for forensics  Kenneth K. Kidd, Andrew J. Pakstis, William C.

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Presentation on theme: "Current sequencing technology makes microhaplotypes a powerful new type of genetic marker for forensics  Kenneth K. Kidd, Andrew J. Pakstis, William C."— Presentation transcript:

1 Current sequencing technology makes microhaplotypes a powerful new type of genetic marker for forensics  Kenneth K. Kidd, Andrew J. Pakstis, William C. Speed, Robert Lagacé, Joseph Chang, Sharon Wootton, Eva Haigh, Judith R. Kidd  Forensic Science International: Genetics  Volume 12, Pages (September 2014) DOI: /j.fsigen Copyright © 2014 The Authors Terms and Conditions

2 Fig. 1 Average heterozygosity and Fst values for 31 independent microhaplotypes in 54 populations. The loci are labeled by gene name and chromosome number referring to descriptions in Table 1; loci are ordered here by average heterozygosity. The full distribution of heterozygosities is given in Supplemental Fig. S1. Forensic Science International: Genetics  , DOI: ( /j.fsigen ) Copyright © 2014 The Authors Terms and Conditions

3 Fig. 2 Match probabilities and most common genotype frequency in 54 populations based on 31 microhaplotypes. The populations are indicated across the bottom in an approximate geographic order as in Supplemental Table S1. Forensic Science International: Genetics  , DOI: ( /j.fsigen ) Copyright © 2014 The Authors Terms and Conditions

4 Fig. 3 Principal components analysis based on TAU genetic distance matrix for 31 independent microhaps in 54 population samples. The first 2 principal components account for 69.6% of the variation among populations; the third accounts for an additional 12.3% and the plot of PC1 by PC3 is in supplemental material. Forensic Science International: Genetics  , DOI: ( /j.fsigen ) Copyright © 2014 The Authors Terms and Conditions

5 Fig. 4 Selected population-specific microhap allele frequencies as stacked bars illustrating different global patterns of haplotype frequencies, indicated as colors. Populations are arrayed in an approximate geographic order as in Supplemental Table S1. (a) The microhap frequencies at RXRA illustrate a locus with low Fst most suitable for individual or lineage identification irrespective of population. The haplotypes are defined by the nucleotide alleles at rs and rs (b) The microhap frequencies at EDAR illustrate a locus with high Fst most suitable for ancestry inference. The five observed haplotypes (of eight possible) are defined by the nucleotide alleles at rs260694, rs , and rs Forensic Science International: Genetics  , DOI: ( /j.fsigen ) Copyright © 2014 The Authors Terms and Conditions

6 Forensic Science International: Genetics 2014 12, 215-224DOI: (10
Forensic Science International: Genetics  , DOI: ( /j.fsigen ) Copyright © 2014 The Authors Terms and Conditions

7 Forensic Science International: Genetics 2014 12, 215-224DOI: (10
Forensic Science International: Genetics  , DOI: ( /j.fsigen ) Copyright © 2014 The Authors Terms and Conditions

8 Forensic Science International: Genetics 2014 12, 215-224DOI: (10
Forensic Science International: Genetics  , DOI: ( /j.fsigen ) Copyright © 2014 The Authors Terms and Conditions

9 Forensic Science International: Genetics 2014 12, 215-224DOI: (10
Forensic Science International: Genetics  , DOI: ( /j.fsigen ) Copyright © 2014 The Authors Terms and Conditions


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