Presentation is loading. Please wait.

Presentation is loading. Please wait.

Glycolysis.

Similar presentations


Presentation on theme: "Glycolysis."— Presentation transcript:

1 Glycolysis

2 Overview of glucose metabolism
Pathway Function glycolysis, citric acid cycle, respiratory chain complete degradation of glucose for ATP production hexose monophosphate shunt degradation of glucose for regeneration of NADPH glycogen synthesis and degradation short-term glucose storage gluconeogenesis synthesis of glucose from amino acids, lactate, or acetone

3 The place of glycolysis in glucose degradation

4 Alternate structures of D-glucose

5 Reactions in glycolysis

6 The phosphate groups in ATP are shielded from nucleophilic attack

7 The catalytic mechanism of hexokinase

8 Hexokinase envelopes its substrates to prevent ATP hydrolysis

9 Phosphohexose isomerase performs acid-base catalysis

10 Glyceraldehyde-3-phosphate dehydrogenase carries out covalent catalysis

11 Structure and redox chemistry of NAD+ and NADP+

12 Pyruvate Kinase

13 Energy-rich functional groups in substrates of glycolysis
the enolphosphate in PEP the carboxyphosphate in 1,3-bisphosphoglycerate the thioester in the active site of glyceraldehyde-3-dehydrogenase

14 Regeneration of cytosolic NAD+ under aerobic conditions

15 Under anaerobic conditions, NAD+ is regenerated by lactate dehydrogenase

16 Ethanolic fermentation in yeast serves a dual purpose

17 Kinetics of glucose transport by facilitated diffusion

18 GLUT transporters in different tissues vary in their affinity for glucose

19 Reaction velocities of hexokinase and glucokinase


Download ppt "Glycolysis."

Similar presentations


Ads by Google