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Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: A randomized, double-blind, placebo-controlled clinical trial 

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Presentation on theme: "Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: A randomized, double-blind, placebo-controlled clinical trial "— Presentation transcript:

1 Effect of intravenous N-acetylcysteine on outcomes after coronary artery bypass surgery: A randomized, double-blind, placebo-controlled clinical trial  Ismail El-Hamamsy, MD, Louis-Mathieu Stevens, MD, Michel Carrier, MD, Michel Pellerin, MD, Denis Bouchard, MD, Philippe Demers, MD, Raymond Cartier, MD, Pierre Page, MD, Louis P. Perrault, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 133, Issue 1, Pages 7-12 (January 2007) DOI: /j.jtcvs Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 IL-6 levels at different time points between NAC and placebo groups (P = NS). IL-6, interleukin-6; NAC, N-acetylcysteine. The Journal of Thoracic and Cardiovascular Surgery  , 7-12DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Comparison of postoperative troponin T levels between NAC group and placebo. NAC, N-acetylcysteine. The Journal of Thoracic and Cardiovascular Surgery  , 7-12DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Comparison of postoperative CK-MB levels between NAC group and placebo. CK-MB, creatine kinase; NAC, N-acetylcysteine. The Journal of Thoracic and Cardiovascular Surgery  , 7-12DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Comparison of serum creatinine levels between NAC group and placebo (μmol/L). NAC, N-acetylcysteine. POD, Postoperative day. The Journal of Thoracic and Cardiovascular Surgery  , 7-12DOI: ( /j.jtcvs ) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions


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