1. Figure 1. Biotechnology sector’s knowledge base
Target
Identification
EST, Expression Arrays, Positional cloning, SNPs, Proteomics, Transcriptomics, Transgene, Pathway Analysis, Animal Models, Konck-in/out, Systems bioloy, Cheomogenomics, Structural genomics, Homology Modeling, Bioinformatics, Phage display, Metabolomics, Antisense, RNAi, Microarrays
Target Discovery
Target
Validation
Lead
Identification
Combinatorial Chemistry, Chemical Libraries, Natural Products, In silico modeling, Microtechnology, Robotics, Microassys, Detection systems, Chemoinformatics, Molecular Modeling, Medicinal Chemistry, ADME (Absorption, Distribution, Metabolism, Excretion), Toxicity, High Throughput Screening, High Throughput Profiling
Drug Discovery
Lead
Optimization
Pre-clinical & Development
Candidate
Development
Toxoicogenomics, Pharmacogenomics, Pharmacogenetics, Animal testing, Carcinogenicity, Biomarkers, Cell-based assays

2. Information Management Knowledge Generation
Reiteration
Technology Sourcing
Information Management
Knowledge Generation
Exploration
Organizational framework
Exploitation
Firm based on sole technology:
Competitive Positioning
Firm based on knowledge accumulation:
Competitive Sustainability
Flexibility: Revision of initial business plan in face of uncertainty
Figure 2. Organizational learning process in the drug discovery process

3. Combinatorial Chemistry
Harmonization
Structural Biology
Information
Generation
Harmonization
Information
Toxicity
Generation I
NTEGRAT ON
Harmonization
Information
ADME
Generation
Harmonization
Information
Profiling
Generation
PROCESS
ING
Harmonization
Generation
Information
HTS
Harmonization
Knowledge Creation
Generation
Information
Microarray
Harmonization
Generation
Proteomics
Information
Harmonization
Generation
Information
Genomics
Harmonization
Functional Genomics
Generation
Information
Harmonization
Combinatorial Chemistry
Generation
Information
Harmonization
Figure 3
In silico Chemistry
Generation
Information

4. Information Management
Discovery & Preclinical phases
Development & Approvals phases
Information Management
- Standardization
- Data Integrity
Knowledge Generation
- Integration
- Processing
Phase 1
Phase 2
Phase 3
Regulatory
Reiteration
- Identification
- Selection
- Validation
Technology Sourcing
Figure 4