1. National and International Efforts worth knowing about
Rebecca Crowley Jacobson, MD, MS
Department of Biomedical Informatics
Institute for Personalized Medicine
University of Pittsburgh Cancer Institute

2. Outline TCGA – done/Adrian Personalized Medicine Initiative
Cancer Moonshot
GA4GH

3. Precision Medicine Initiative
$215M initial investment (2016)

4. The Cohort 1 million Americans Prospective
Participant focused, highly interactive
Individual volunteers
Enrollment Centers (Pitt applied)
Eric Dishman, Director

5. Purpose of the Cohort
develop ways to measure risk for a range of diseases based on environmental exposures, genetic factors and interactions between the two;
identify the causes of individual differences in response to commonly used drugs (commonly referred to as pharmacogenomics);
discover biological markers that signal increased or decreased risk of developing common diseases;
use mobile health (mHealth) technologies to correlate activity, physiological measures and environmental exposures with health outcomes;
develop new disease classifications and relationships;
empower study participants with data and information to improve their own health; and
create a platform to enable trials of targeted therapies.
Adapted from the NIH website

6. Participants
volunteer to share core data including their electronic health records, health survey information, and mobile health data on lifestyle habits and environmental exposures.
undergo a standard baseline exam for vital signs, medication assessment, and past medical history, and provide a blood sample. 

7. Working on essential framework
Governance and Trust
Data Security

8. Cancer Moonshot http://www.cancermoonshot2020.org/
Budget request for ~$680M

9. Areas of Interest Cancer Vaccine Development Early Cancer Detection
Immunotherapy and Combined Tx
Tumor genomic profiling
Data Sharing
Pediatric Cancer
FDA Oncology Center of Excellence
VP Exceptional Opportunities in CR Fund

10. What have they done so far
Task Force
Working Groups
Communication
Most folks do expect RFAs eventually

11. GA4GH
Global alliance of institutions of all kinds that re working together to “establish, broadly disseminate, and advocate for the use of interoperable technical standards for managing and sharing genomic and clinical data.”

12. Work Process