1. (A) Simulation of propofol effect-site concentrations (Ce) that result from a bolus (2 mg/kg) and 1-hour infusion (150 mcg/kg/min) for a 53-year-old 155-cm (5’1”) female. (B) Simulation of probability of unresponsiveness after a 2 mg/kg bolus and 1 hour infusion (150 mcg/kg/min) for a 53-year-old 155-cm (5’1”) female. Simulations include 2 dosing weights: (1) total body weight (TBW) of 60 kg with a body mass index (BMI) of 25 kg/m2 and (2) 140 kg with a BMI of 58 kg/m2. Simulations also include several weight scalars for the 140-kg weight: FFM, fat-free mass; MFFM, modified fat-free mass; LBM, lean body mass; and IBW, ideal body weight. Estimates of propofol Ce levels were made using pharmacokinetic parameters published by Cortinez et al.17 Predictions of loss of responsiveness were made using the pharmacodynamic model published by Kern et al.23
Source: Implications of Obesity on Anesthetic Drug Behavior, Clinical Pharmacology for Anesthesiology
Citation: Johnson KB. Clinical Pharmacology for Anesthesiology; 2015 Available at: Accessed: November 12, 2017
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