1. PCSK9 Inhibition—A New Thrust in the Prevention of Heart Disease: Genetics Does It Again 
Robert Roberts, MD, FRCPC, MACC 
Canadian Journal of Cardiology 
Volume 29, Issue 8, Pages (August 2013)
DOI: /j.cjca
Copyright © 2013 Canadian Cardiovascular Society Terms and Conditions

2. Figure 1
This illustrates that low-density lipoprotein (LDL) and its cholesterol (LDL-C) are synthesized in the liver and released into the circulation. The liver is also responsible for removing LDL-C from the circulation. The circulating LDL-C binds to the LDL receptor (LDL-R) on the surface of the liver cells, which internalizes the LDL-C/LDL-R complex to be degraded.
Canadian Journal of Cardiology  , DOI: ( /j.cjca )
Copyright © 2013 Canadian Cardiovascular Society Terms and Conditions