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The predictive value of creatine phosphokinase and alkaline phosphatase in identification of heterotopic ossification in patients after spinal cord injury1 

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Presentation on theme: "The predictive value of creatine phosphokinase and alkaline phosphatase in identification of heterotopic ossification in patients after spinal cord injury1 "— Presentation transcript:

1 The predictive value of creatine phosphokinase and alkaline phosphatase in identification of heterotopic ossification in patients after spinal cord injury1  Rajendra S Singh, MD, Michael C Craig, MD, Charles R Katholi, PhD, Amie B Jackson, MD, James M Mountz, MD, PhD  Archives of Physical Medicine and Rehabilitation  Volume 84, Issue 11, Pages (November 2003) DOI: /S (03)

2 Fig 1 (A) AP radiograph of the pelvis and (B) technetium 99m (Tc-99m) methylene diphosphonate (MDP) bone single-photon emission computed tomography (SPECT) scan section of patient 7 (table 1) 21 days after injury. The CPK level was 888U/dL (normal range, 35–250U/dL) and ALP was 76U/dL (normal range, 35–117U/dL). Both the radiograph and bone scan are normal. Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (03) )

3 Fig 2 (A) AP radiograph of the pelvis and (B) Tc 99m MDP SPECT scan section of the same patient 3 months after SCI. Grade 4 HO (arrows) can be seen on the radiograph, which corresponds to the area of increased Tc 99m MDP uptake on the bone scan. Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (03) )

4 Fig 3 Scatterplot of group 1 showing values of CPK plotted against grade of HO. The 2 lines represent the normal range of values of CPK. There is a strong correlation between the values of CPK and severity of HO (R=.947, P<.0024). Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (03) )

5 Fig 4 Scatterplot of group 1 showing values of ALP (ALK PHOS) plotted against grade of HO. The 2 lines represent the normal range for values of ALP. There is no correlation between the values of ALP and subsequent development of HO. Archives of Physical Medicine and Rehabilitation  , DOI: ( /S (03) )


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