1. MGSD Studies
Genetic diagnosis of atypical non-automimmune diabetes: M. Marre (France)

2. Genetic diagnosis of atypical non-autoimmune diabetes in the Mediterranean area
Prof. Michel Marre

3. Monogenic diabetes study in the Mediterranean region
Cross-sectional, multicentre and multinational study covering the Mediterranean region to detect monogenic diabetes among patients suspected to be with atypical diabetes
Objective: to provide diabetes specialists with an innovative tool to diagnose new cases of atypical non-autoimmune diabetes among their patients in order to improve patient care
Methodology: genetic analysis of saliva sample with a PCR- based enrichment technology in combination with massively parallel sequencing at a unique visit

4. Inclusion / exclusion criteria
Inclusion criteria
Patients suspected of having atypical diabetes and followed for the disease in the different study centers
Adults and underage children
Selection procedure will rely on the investigator assessment, helped by the use of the MODY risk calculator (>25%)
Exclusion criteria
Secondary diabetes due to pancreatic disease, diabetogenic drug, endocrine disease
Type 1 diabetes as established by the investigator.

5. Genetic analysis
Performed by the European Genomic Institute for Diabetes (EGID)
Technique: genetic analysis of saliva sample with a PCR-based enrichment technology in combination with massively parallel sequencing at a unique visit
Results will be analyzed by EGID to establish the diagnosis of monogenic diabetes

6. France
Serbia
Turkey
Greece
Cyprus
Malta
Lebanon
Morocco
Tunisia
Algeria

7. 10 Participating countries, 45 centers
250 patients
Country
National coordinator
Nb of centers
Nb of investigators
Algeria
Prof. Azzedine Belhadj 4 12
Cyprus
Dr. Doros Loizou
France
Prof. Michel Marre 13
Greece
Prof Stravos Liatis 5 7
Lebanon
Dr Rita Medlej 1
Malta
Prof. Josanne Vassallo
Morocco
Prof. Asma Chadli
Serbia
Prof. Nebojsa Lalic
Turkey
Prof. Hassan Ilkova 10 11
Tunisia
Prof Leila Ben Salem 3

8. Update on the inclusions
France
Serbia
Turkey
Greece
Cyprus
Malta
Lebanon
Morocco
Tunisia
Algeria

9. End of analysis + results
Timeline
Material shipment
Inclusion
Genetic analysis
Feb 2017
Oct 2017
End of inclusion
Results mailing
Mar 2018
Statistic analysis
Medical writing
End of analysis + results
May 2018
Study
data
Apr 2017

10. Thank you