1. CRAHW
Centre for Research on Ageing, Health & Wellbeing
Ageing well through the prevention of dementia: A protocol for a multidomain MCI intervention
Mitchell McMaster, Linda Clare, Sarang Kim, Kaarin Anstey
Centre for Research on Ageing, Health & Wellbeing (CRAHW)
The Australian National University

2. Overview Background Dementia Prevention for MCI
Body, Brain, Life Project
BBL-MCI Modifications
Methodology
Outcome Measures
Defining A Successful Outcome

3. Background
Growing consensus re: risk factors and efficacy of prevention (Beydoun, et al, 2014; Norton, et al, 2014)
Preventable cases of dementia (Barnes & Yaffe, 2011)
One of the highest risk groups are individuals with MCI (Plassman, et al, 2008)
Need for more research in this area (Williams et al, 2010; Plassman, et al, 2008; Norton, 2014)

4. Dementia Prevention for MCI
What is MCI?
Currently there is uncertainty around the point at which interventions can still have a positive effect on the disease trajectory.
-Emergence of pathology
-MCI variability (progression vs remission) (Plassman et al, 2008; Malek-Almadi, 2016)
-Several authors have identified MCI as a point where there should be increased research as a possibility for prevention and risk reduction

5. Body Brain Life Project (BBL) Progression
BBL: Multidomain dementia risk-reduction intervention.
- Dementia Literacy - Risk Factors
- Physical activity - Diet Cognitive Engagement - Social Engagement Health Management Mood
Practical Components
Study
Year Conducted
Risk Factors
Mood
Physical Activity
Diet
Cognitive Activity
BBL
2013 P ×
BBL-FIT
2015
BBL-GP
2016
BBL-MCI
2017

6. BBL-MCI Modifications
Online modules reduced
Complexity reduced
Memory aids
Additional “active” components
-Physical activity
-Nutrition
-Cognitive engagement
The program will be piloted with Alzheimer’s Australia to determine feasibility issues with MCI population

7. Methodology
Population: Mild Cognitive Impairment/Subjective Memory Impairment
Intervention vs active control
Testing to take place at 4 time points: Baseline, post-intervention, 3 months and 6 months.

8. Outcome Measures Primary outcome: Functionality -Cognitive measures
-IADLs
Secondary outcome: Dementia Risk Reduction/Cost Effectiveness
-ANU-ADRI
-SF 12

9. Defining A Successful Outcome
Prevention vs. Trajectory Modification
(Adapted from Rosenberg, 2015)

10. Financial Support
This PhD is supported by Alzheimer’s Australia Dementia Research Foundation (AADRF), Dementia Collaborative Research Centres (DCRC), Australian National University (ANU) 1:1 Scholarship

11. References
Beydoun, M.A., et al.(2014). Epidemiologic studies of modifiable factors associated with cognition and dementia: Systematic review and meta- analysis. BMC Public Health, 14(1),
Norton, S., et al. (2014) Potential for primary prevention of Alzheimer’s disease: An analysis of population-based data. Lancet Neurology, 13(8),
Barnes, D. & Yaffe, K. (2011). The projected effect of risk factor reduction on Alzheimer’s disease prevalence. Lancet Neurology, 10,
Plassman, B.L., et al. (2008). Prevalence of cognitive impairment without dementia in the United States. Annals of Internal Medicine, 148(6),
Williams, J.W., et al. (2010) Prevention Alzheimer's Disease and cognitive decline, in Evidence Report/Technology Assessment. Rockville, MD: Agency for Healthcare Research and Quality (US).
Rosenberg, I. H. (2015). Keynote address: Aging and the nutrition imperative. New York Academy of Sciences eBriefing.

12. Thank you!