Presentation is loading. Please wait.

Presentation is loading. Please wait.

Islet Transplantation and Insulin Administration Relieve Long-Term Complications and Rescue the Residual Endogenous Pancreatic β Cells  Marina Figliuzzi,

Published byGeorgia Morgan Modified over 5 years ago

Similar presentations

Presentation on theme: "Islet Transplantation and Insulin Administration Relieve Long-Term Complications and Rescue the Residual Endogenous Pancreatic β Cells  Marina Figliuzzi,"— Presentation transcript:

1 Islet Transplantation and Insulin Administration Relieve Long-Term Complications and Rescue the Residual Endogenous Pancreatic β Cells  Marina Figliuzzi, Roberto Bianchi, Cristina Cavagnini, Raffaella Lombardi, Carla Porretta-Serapiglia, Giuseppe Lauria, Federica Avezza, Annalisa Canta, Valentina Carozzi, Alessia Chiorazzi, Paola Marmiroli, Cristina Meregalli, Norberto Oggioni, Barbara Sala, Guido Cavaletti, Andrea Remuzzi  The American Journal of Pathology  Volume 183, Issue 5, Pages (November 2013) DOI: /j.ajpath Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

2 Figure 1 Blood glucose (A) and body weight (B) in male Sprague–Dawley rats. Data are expressed as means ± SEM. P < for control versus all other groups at all time points. P < for hyperglycemia versus all other groups at all time point. ∗P < 0.05, ∗∗P < for islet transplantation versus mild hyperglycemia. †P < 0.05 for control versus islet transplantation. ‡P < 0.05 for hyperglycemia versus mild hyperglycemia. §P < 0.05, §§P < for moderate hyperglycemia versus islet transplantation. ¶P < 0.05, ¶¶P < for moderate hyperglycemia versus mild hyperglycemia. The American Journal of Pathology  , DOI: ( /j.ajpath ) Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

3 Figure 2 OGTT blood glucose values in male Sprague–Dawley rats at 4 months (A) and 8 months (B). Data are expressed as means ± SEM. The American Journal of Pathology  , DOI: ( /j.ajpath ) Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

4 Figure 3 A and B: Thermal (A) and mechanical (B) nociceptive threshold over time. C and D: Nerve conduction velocity in the tail vein at 8 months (C) and Na+-K+-ATPase activity at 8 months (D). Data are expressed as means ± SEM. ∗P < 0.05 for control versus moderate hyperglycemia, mild hyperglycemia, and islet transplantation. ∗∗P < for control versus hyperglycemia, moderate hyperglycemia, and mild hyperglycemia. †P < 0.05 for hyperglycemia versus moderate hyperglycemia, mild hyperglycemia, and islet transplantation. ††P < for hyperglycemia versus mild hyperglycemia and islet transplantation. The American Journal of Pathology  , DOI: ( /j.ajpath ) Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

5 Figure 4 Representative images of sciatic nerve in control, hyperglycemic, and islet transplantation groups of rats. Degenerating fibers in hyperglycemic animals are indicated by arrows. Scale bar = 25 μm. Original magnification, ×40. The American Journal of Pathology  , DOI: ( /j.ajpath ) Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

6 Figure 5 Representative images of stained glucagon cells in the five groups of rats at the end of the study. Two images for islet transplantation are shown Scale bar = 25 μm. Original magnification, ×20. The American Journal of Pathology  , DOI: ( /j.ajpath ) Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

7 Figure 6 β-Cell analysis at 4 and 8 months in Sprague–Dawley rats for volume density of β cells (A), mean area of positive insulin cells (B), and β-cell density per unit of volume (C). Data are expressed as means ± SEM. ∗P < 0.05 for control versus hyperglycemia and islet transplantation. ∗∗P < for control versus all other groups. ‡P < 0.05 for hyperglycemia versus moderate hyperglycemia, mild hyperglycemia, and islet transplantation. ‡‡P < for hyperglycemia versus moderate hyperglycemia and islet transplantation. ‡P < 0.05 for moderate hyperglycemia versus islet transplantation. §P < 0.05 for islet transplantation versus mild hyperglycemia. The American Journal of Pathology  , DOI: ( /j.ajpath ) Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

8 Figure 7 Representative images of stained insulin cells in the groups of rats at 8 months (end of study). Scale bars: 200 μm (left); 50 μm (right). The American Journal of Pathology  , DOI: ( /j.ajpath ) Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

9 Figure 8 Correlation between volume density of β cells and log value of blood glucose at 4 months (A) and 8 months (B). The American Journal of Pathology  , DOI: ( /j.ajpath ) Copyright © 2013 American Society for Investigative Pathology Terms and Conditions

Download ppt "Islet Transplantation and Insulin Administration Relieve Long-Term Complications and Rescue the Residual Endogenous Pancreatic β Cells  Marina Figliuzzi,"

Similar presentations

Accelerated Loss of Islet β Cells in Sucrose-Fed Goto-Kakizaki Rats, a Genetic Model of Non-Insulin-Dependent Diabetes Mellitus Motoi Koyama, Ryu-ichi.

Accelerated Loss of Islet β Cells in Sucrose-Fed Goto-Kakizaki Rats, a Genetic Model of Non-Insulin-Dependent Diabetes Mellitus Motoi Koyama, Ryu-ichi.
CC Chemokine Receptor 5 and CXC Chemokine Receptor 6 Expression by Lung CD8+ Cells Correlates with Chronic Obstructive Pulmonary Disease Severity Christine.

CC Chemokine Receptor 5 and CXC Chemokine Receptor 6 Expression by Lung CD8+ Cells Correlates with Chronic Obstructive Pulmonary Disease Severity Christine.
Telomerase Activity and Expression of Telomerase RNA Component and Telomerase Catalytic Subunit Gene in Cervical Cancer Kenji Nakano, Elizabeth Watney,

Telomerase Activity and Expression of Telomerase RNA Component and Telomerase Catalytic Subunit Gene in Cervical Cancer Kenji Nakano, Elizabeth Watney,
CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.

CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.
Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.

Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.
Teratoma Formation Leads to Failure of Treatment for Type I Diabetes Using Embryonic Stem Cell-Derived Insulin-Producing Cells  Takahisa Fujikawa, Seh-Hoon.

Teratoma Formation Leads to Failure of Treatment for Type I Diabetes Using Embryonic Stem Cell-Derived Insulin-Producing Cells  Takahisa Fujikawa, Seh-Hoon.
Reduced Level of CD44 and Hyaluronan Associated with Unfavorable Prognosis in Clinical Stage I Cutaneous Melanoma  Jari M. Karjalainen, Raija H. Tammi,

Reduced Level of CD44 and Hyaluronan Associated with Unfavorable Prognosis in Clinical Stage I Cutaneous Melanoma  Jari M. Karjalainen, Raija H. Tammi,
Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures  Vitalba.

Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures  Vitalba.
Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin.

Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin.
Journal of Surgical Research

Journal of Surgical Research
Monocyte/Macrophage MMP-14 Modulates Cell Infiltration and T-Cell Attraction in Contact Dermatitis But Not in Murine Wound Healing  Anke Klose, Paola.

Monocyte/Macrophage MMP-14 Modulates Cell Infiltration and T-Cell Attraction in Contact Dermatitis But Not in Murine Wound Healing  Anke Klose, Paola.
Sophie Croizier, Vincent Prevot, Sebastien G. Bouret  Cell Reports 

Sophie Croizier, Vincent Prevot, Sebastien G. Bouret  Cell Reports 
Prolonged Repetitive Head Trauma Induces a Singular Chronic Traumatic Encephalopathy–Like Pathology in White Matter Despite Transient Behavioral Abnormalities 

Prolonged Repetitive Head Trauma Induces a Singular Chronic Traumatic Encephalopathy–Like Pathology in White Matter Despite Transient Behavioral Abnormalities 
Monocyte Traffic, Dorsal Root Ganglion Histopathology, and Loss of Intraepidermal Nerve Fiber Density in SIV Peripheral Neuropathy  Jessica R. Lakritz,

Monocyte Traffic, Dorsal Root Ganglion Histopathology, and Loss of Intraepidermal Nerve Fiber Density in SIV Peripheral Neuropathy  Jessica R. Lakritz,
Volume 15, Issue 5, Pages (May 2016)

Volume 15, Issue 5, Pages (May 2016)
Bone Marrow Transplant Engraftment Analysis with Loss of an Informative Allele  Steven A. Schichman, Pei Lin, Lori J. Gilbrech, Pamela S. Gray, Carla S.

Bone Marrow Transplant Engraftment Analysis with Loss of an Informative Allele  Steven A. Schichman, Pei Lin, Lori J. Gilbrech, Pamela S. Gray, Carla S.
Multiple Microvascular Alterations in Pancreatic Islets and Neuroendocrine Tumors of a Men1 Mouse Model  Xia Chu, Xiang Gao, Leif Jansson, My Quach, Britt.

Multiple Microvascular Alterations in Pancreatic Islets and Neuroendocrine Tumors of a Men1 Mouse Model  Xia Chu, Xiang Gao, Leif Jansson, My Quach, Britt.
Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model  Ana Hidalgo-Sastre, Roxanne L.

Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model  Ana Hidalgo-Sastre, Roxanne L.
Engraftment of Cells from Porcine Islets of Langerhans and Normalization of Glucose Tolerance Following Transplantation of Pig Pancreatic Primordia in.

Engraftment of Cells from Porcine Islets of Langerhans and Normalization of Glucose Tolerance Following Transplantation of Pig Pancreatic Primordia in.
Robert G. Presson, Mary Beth Brown, Amanda J. Fisher, Ruben M

Robert G. Presson, Mary Beth Brown, Amanda J. Fisher, Ruben M

Similar presentations

Ads by Google