2. Key Points
LKB1 regulates cell polarity and functions as a haplo-insufficient tumor suppressor
LKB1 activates the AMPK cascade to suppress growth and proliferation
Loss of LKB1 enhances tumorigenesis as a secondary mutation

3. Peutz-Jeghers Syndrome leads to noncancerous growths called hamartomatous polyps in the gastrointestinal tract

4. LKB1 encodes a serine/threonine kinase

5. LKB1 is bound and activated by STRAD, inducing G1 cell cycle arrest

6. AMPK is a master regulator of cellular energy homeostasis

7. The LKB1/AMPK/TSC/mTORC1 Pathway is often mutated in Cancers

8. LKB1 loss in Mice

9. Works Cited
Huret JL . STK11 (serine/threonine kinase 11). Atlas Genet Cytogenet Oncol Haematol. February
URL :
Bapat B, Perera S . STK11 (serine/threonine kinase 11). Atlas Genet Cytogenet Oncol Haematol. January
"AMPK Signaling." Cell Signaling Technology. Cell Signaling Technology, Inc, Apr Web. 10 Apr
Babineaux, M., Gabriel Lee, and Andrew W. DuPont. "Intussuception in Peutz-Jegher Syndrome." DAVE Project-Gastroenterology. Pentax Medical, 21 Jan Web. 10 Apr
Korsse, S. E., M. P. Peppelenbosch, and W. V. Veelen. "Targeting LKB1 Signaling in Cancer." ScienceDirect.com. Erasmus Medical University Center, Apr Web. 10 Apr
"Peutz-Jeghers Syndrome." Genetics Home Reference. US National Library of Medicine, 9 Feb Web. 10 Apr
Shaw, Reuben J., Katja A. Lamia, Debbie Vasquez, Seung-Hoi Koo, Nabeel Bardeesy, Ronald A. DePinho, Marc Montminy, and Lewis C. Cantley. "The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin." Science, 9 Dec Web. 1 Apr
"STK11." Serine/threonine Kinase 11. US National Library of Medicine, Aug Web. 10 Apr
Veelen, W. V., S. E. Korsse, L. V. Laar, and M. P. Peppelenbosch. "The Long and Winding Road to Rational Treatment of Cancer Associated with LKB1/AMPK/TSC/mTORC1 Signaling." Oncogene. Nature, 24 Jan Web. 1 Apr
Zeqiraj, E., BM Filippi, S. Goldie, I. Navratilova, J. Boudeau, M. Deak, D. R. Alessi, and D. M. Van Aalten. "ATP and MO25 Regulate the Conformational State of the STRAD Pseudokinase and Activation of the LKB1 Tumour Suppressor." PubMed.gov. US National Library of Medicine, 9 June Web. 1 Apr