1. Lecture 3 Dr.Narmin Hussen15
Dopamine
Lecture 3
Dr.Narmin Hussen

2. Dopamine Some of its notable functions are in: movement memory
pleasurable reward
behavior and cognition
Attention
inhibition of prolactin production
sleep
mood
learning

3. Dopaminergic Pathways

4. Synthesis of Dopamine
precursor of norepinephrine and epinephrine.

5. Dopamine Receptors
DA receptors are divided into five subtypes, D1 to D5

6. Dopamine Metabolism

7. Parkinson Disease
PD is a progressive neurodegenerative, dopamine deficiency disorder

8. video mp4

9. Symptoms of Parkinson's disease
Slowness of movement and Shuffling walk
Tremor (shaking)
Muscle rigidity (Stiffness)
Muffled speech

11. Risk factor Age Genetic factors Head Injury Environmental factors
Gender

12. Diagnosis of Parkinson's disease
Clinical features
Brain scans(CT or MRI)

13. Treatment
Levodopa:

14. Levodopa/Carbidopa (sinemet):

15. MAO-B Inhibitors: 1(R)-aminoindan, 3-hydroxy-N-propargyl-1-aminoindan,
and 3-hydroxy-1-aminoindan
a selective irreversible inhibitor of MAO-B

16. Dopamine Agonists DA agonists are classified into:
Ergot derivatives (pergolide, cabergoline, and bromocriptine)
withdrawn from the market.

17. Nonergot derivatives (apomorphine, pramipexole, ropinirole, and rotigotine).
, 4-carboxymethylindolin-2-one
N-despropylrotigotine and
N-desthienylethyl rotigotine

19. COMT Inhibitors: only inhibits peripheral COMT
Tolcapone is a selective and reversible
inhibitor of COMT in the CNS and periphery
Entacapone does not penetrate the BBB