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Congenital cytomegalovirus infection: patterns of fetal brain damage

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Presentation on theme: "Congenital cytomegalovirus infection: patterns of fetal brain damage"— Presentation transcript:

1 Congenital cytomegalovirus infection: patterns of fetal brain damage
L. Gabrielli, M.P. Bonasoni, D. Santini, G. Piccirilli, A. Chiereghin, E. Petrisli, R. Dolcetti, B. Guerra, M. Piccioli, M. Lanari, M.P. Landini, T. Lazzarotto  Clinical Microbiology and Infection  Volume 18, Issue 10, Pages E419-E427 (October 2012) DOI: /j x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

2 FIG. 1. Laminar necrosis in the third cortical layer (between the two arrows). The cortex has an irregular contour with deepening of the immature sulci, suggestive of early polymicrogyria. Haematoxylin and eosin, ×10. Clinical Microbiology and Infection  , E419-E427DOI: ( /j x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

3 FIG. 2. Cerebral white matter. Immunohistochemistry, ×40. (a) A microglial nodule with a cytomegalic cell (arrow) surrounded by CD8+ T-lymphocytes (CD8 as brown cell marker). (b) A cytomegalic cell (arrow) surrounded by activated (granzyme B-positive) cytotoxic CD8+ T-lymphocytes (granzyme B as a brown marker of cytotoxic activation). Clinical Microbiology and Infection  , E419-E427DOI: ( /j x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

4 FIG. 3. Tissue viral load in fetuses with different degrees of brain damage. The bars show the mean viral load values and the interquartile range for each group. Clinical Microbiology and Infection  , E419-E427DOI: ( /j x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions


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