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Flushing Profile of Extended-Release Niacin/Laropiprant Versus Gradually Titrated Niacin Extended-Release in Patients With Dyslipidemia With and Without.

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Presentation on theme: "Flushing Profile of Extended-Release Niacin/Laropiprant Versus Gradually Titrated Niacin Extended-Release in Patients With Dyslipidemia With and Without."— Presentation transcript:

1 Flushing Profile of Extended-Release Niacin/Laropiprant Versus Gradually Titrated Niacin Extended-Release in Patients With Dyslipidemia With and Without Ischemic Cardiovascular Disease  Darbie Maccubbin, PhD, Michael J. Koren, MD, Michael Davidson, MD, Dov Gavish, MD, Richard C. Pasternak, MD, Geraldine Macdonell, MHA, Madhuja Mallick, PhD, Christine McCrary Sisk, BS, John F. Paolini, MD, PhD, Yale Mitchel, MD  American Journal of Cardiology  Volume 104, Issue 1, Pages (July 2009) DOI: /j.amjcard Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Study design. e-diaries = electronic diaries; PBO = placebo; R = randomization. American Journal of Cardiology  , 74-81DOI: ( /j.amjcard ) Copyright © 2009 Elsevier Inc. Terms and Conditions

3 Figure 2 Number of days per week with moderate, severe or extreme flushing (GFSS ≥4) across the treatment period, categorized as 0 day (black bars), >0 and ≤0.5 day (dotted bars), >0.5 and ≤1 day (striped bars), >1 and ≤2 days (dark gray bars), >2 and ≤3 days (white bars), and >3 days (light gray bars) per week. American Journal of Cardiology  , 74-81DOI: ( /j.amjcard ) Copyright © 2009 Elsevier Inc. Terms and Conditions

4 Figure 3 (A) Mean ± SE number of days per week and (B) percentage of patients with moderate, severe, or extreme flushing (GFSS ≥4) by week. American Journal of Cardiology  , 74-81DOI: ( /j.amjcard ) Copyright © 2009 Elsevier Inc. Terms and Conditions

5 Figure 4 Cumulative discontinuations due to (A) flushing and (B) flushing plotted against cumulative dose of niacin. American Journal of Cardiology  , 74-81DOI: ( /j.amjcard ) Copyright © 2009 Elsevier Inc. Terms and Conditions

6 Figure 5 Changes over time in (A) low-density lipoprotein cholesterol (LDL-C), (B) high-density lipoprotein cholesterol (HDL-C), and (C) triglyceride. *Percent change from baseline (average of weeks 8 through 16). American Journal of Cardiology  , 74-81DOI: ( /j.amjcard ) Copyright © 2009 Elsevier Inc. Terms and Conditions

7 Figure 6 Cumulative discontinuations due to (A) nonflushing clinical and laboratory AEs and (B) nonflushing clinical and laboratory AEs plotted against cumulative dose of niacin. American Journal of Cardiology  , 74-81DOI: ( /j.amjcard ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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