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Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam– Generated Neutrons  Leo E. Gerweck, PhD, Peigen Huang, MD, Hsiao-Ming.

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Presentation on theme: "Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam– Generated Neutrons  Leo E. Gerweck, PhD, Peigen Huang, MD, Hsiao-Ming."— Presentation transcript:

1 Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam– Generated Neutrons  Leo E. Gerweck, PhD, Peigen Huang, MD, Hsiao-Ming Lu, PhD, Harald Paganetti, PhD, Yenong Zhou, BS  International Journal of Radiation Oncology • Biology • Physics  Volume 89, Issue 1, Pages (May 2014) DOI: /j.ijrobp Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Fig. 1 Conscious active mice in Lucite annuli were exposed to neutrons at a distance of 16.5 to 26.5 cm lateral to the edge of the mid-spread-out Bragg peak. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

3 Fig. 2 Lifetime cumulative (cum.) survival of control and neutron exposed mice. Intentionally sacrificed nonmoribund and abruptly dying mice were censored. N=139 control and 138 neutron exposed mice. Bars are 95% confidence intervals for the control cohort of animals at the 10%, 50% and 90% cumulative survival level and for the exposed mice at the same age as the control mice. Log-rank test P=.053. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

4 Fig. 3 Cumulative deaths as a fraction of all deaths over the lifetime of the mice. (A) Death from cancer of all types (P=.0006). (B) Deaths due to lymphocytic leukemia (P=.004). (C) Death from solid cancer (P=.09). Cum. = cumulative. International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

5 Supplemental Figure 1 International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

6 Supplemental Figure 2 International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

7 Supplemental Figure 3 International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

8 Supplemental Figure 4 International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

9 Supplemental Figure 5 International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

10 Supplemental Figure 6 International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

11 Supplemental Figure 7 International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

12 Supplemental Figure 8 International Journal of Radiation Oncology • Biology • Physics  , DOI: ( /j.ijrobp ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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