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Volume 2, Issue 12, Pages (December 2015)

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1 Volume 2, Issue 12, Pages 1965-1973 (December 2015)
Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: Results of the Prospective Multicenter French Trial  David Azria, Olivier Riou, Florence Castan, Tan Dat Nguyen, Karine Peignaux, Claire Lemanski, Jean-Léon Lagrange, Youlia Kirova, Eric Lartigau, Yazid Belkacemi, Céline Bourgier, Sofia Rivera, Georges Noël, Sébastien Clippe, Françoise Mornex, Christophe Hennequin, Andrew Kramar, Sophie Gourgou, André Pèlegrin, Pascal Fenoglietto, Esat Mahmut Ozsahin  EBioMedicine  Volume 2, Issue 12, Pages (December 2015) DOI: /j.ebiom Copyright © 2015 The Authors Terms and Conditions

2 Fig. 1 Trial profile. EBioMedicine 2015 2, DOI: ( /j.ebiom ) Copyright © 2015 The Authors Terms and Conditions

3 Fig. 2 Cumulative incidence of grade ≥2 late side effects (BF-FS, breast fibrosis-free survival) and relapses (RFS, relapse-free survival). Breast fibrosis component (a) and relapse component (b) for two categories (<12 and ≥12) of radiation-induced lymphocyte apoptosis (RILA) are presented. Breast fibrosis component (c) and relapse component (d) for three categories (<12, 12–20, and ≥20) of RILA are presented. EBioMedicine 2015 2, DOI: ( /j.ebiom ) Copyright © 2015 The Authors Terms and Conditions

4 Fig. 3 Cumulative incidence of first events according to radiation-induced lymphocyte apoptosis (RILA). Univariate (a) and multivariate (b) analyses for three categories (<12, 12–20, and ≥20) of RILA are presented. Univariate (c) and multivariate (d) analyses for two categories (<12 and ≥12) of RILA are presented. EBioMedicine 2015 2, DOI: ( /j.ebiom ) Copyright © 2015 The Authors Terms and Conditions


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