1. Outcome of Neutropenic Fever in Hospitalized Cancer Patients during a one-year Follow-up: a single center experience.
Riwa Sakr1,2, Marcel Massoud1,2, Wafaa Greige1,2, Nathalie Bteich3, Layale Rached1,2, Fadi Nasr1,2, Elie Akoury1,2, Fouad Kerbage1,2, Georges Chahine1,2
1Holy Spirit University of Kaslik, medical school, Lebanon, 2University Hospital Center-Notre Dame de Secours-Jbeil, Lebanon, 3American University Hospital, Lebanon
Introduction
Methods
Results
Results
Conclusion
Febrile neutropenia is a relatively frequent event among cancer patients treated with chemotherapy. Since these patients lack the appropriate immunologic response, early recognition and adequate treatment are crucial. Current guidelines support the administration of IV antibiotics within the first hour of presentation in order to improve the outcome.
Our study demonstrated that the overall mortality rate in our institution is comparable to international centers. The initial choice of antibiotics in our institution meets the international guidelines in the majority of patients. Patients classified as severe by the MASCC score have a higher rate of mortality despite adequate treatment.
An epidemiologic, prospective study was conducted at the Hematology-Oncology Department at Notre Dame de Secours University hospital from September 2015 until December All adult patients admitted to the hospital with the diagnosis of febrile neutropenia were included. A statistical analysis was conducted to identify factors related to poor outcome and overall mortality rate.
References
Discussion
Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis Feb (4):e56-93
Flowers CR, Seidenfeld J, Bow EJ, et al. Antimicrobial prophylaxis and outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol Feb (6):  
KuntegowdanahalliLakshmaiah, Abhayakumar S Malabagi, Govindbabu, Rachan Shetty,Mahua Sinha,1 and Rudrapatna S Jayashree1 Febrile Neutropenia in Hematological Malignancies: Clinical and Microbiological Profile and Outcome in High Risk Patients
Results
Objective
All deaths were associated with infectious reasons except for one.
From the 6 patients who died: 5 were classified as severe by the MASCC score and 1 was classified as moderate. However, all of them were treated adequately regarding to antibiotics. In most cases, no germ was identified in cultures which justifies the pursuit of broad spectrum antibiotics.
47% of patients received a second line of antibiotics after persistence of fever.
This study was conducted in order to determine the outcome and mortality rate of febrile neutropenia in patients admitted to a university hospital during one year, and to evaluate the accuracy of management.
Contact.
Massoud Marcel