1. Contemporary Clinical Trials
PROMIS — Prostate MR imaging study: A paired validating cohort study evaluating the role of multi-parametric MRI in men with clinical suspicion of prostate cancer 
A. El-Shater Bosaily, C. Parker, L.C. Brown, R. Gabe, R.G. Hindley, R. Kaplan, M. Emberton, H.U. Ahmed 
Contemporary Clinical Trials 
Volume 42, Pages (May 2015)
DOI: /j.cct
Copyright © 2015 The Authors Terms and Conditions

2. Fig. 1
Over-detection of insignificant prostate cancer resulting from TRUS-guided biopsies.
Contemporary Clinical Trials  , 26-40DOI: ( /j.cct )
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3. Fig. 2
Under-detection of clinically significant prostate cancer resulting from TRUS-guided biopsies.
Contemporary Clinical Trials  , 26-40DOI: ( /j.cct )
Copyright © 2015 The Authors Terms and Conditions

4. Fig. 3
Current and proposed diagnostic pathways should MP-MRI prove favourable.
Contemporary Clinical Trials  , 26-40DOI: ( /j.cct )
Copyright © 2015 The Authors Terms and Conditions

5. Fig. 4
PROMIS Trial Schema. N.B.: visit one (registration) includes a detailed discussion of the patient information sheet and what to expect from participation in PROMIS. Followed by signing an informed consent and assessment of patient's eligibility.
Contemporary Clinical Trials  , 26-40DOI: ( /j.cct )
Copyright © 2015 The Authors Terms and Conditions

6. Fig. 5 MP-MRI reporting form.
Contemporary Clinical Trials  , 26-40DOI: ( /j.cct )
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7. Fig. 6
Illustration of how Transperineal Template Prostate Mapping biopsies are conducted.
Contemporary Clinical Trials  , 26-40DOI: ( /j.cct )
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8. Fig. 7
Definitions of clinical significance on TTPM-biopsy. Red signifies UCL definition 1 against which the primary outcome will be validated. Yellow signifies UCL definition 2 and is a secondary outcome.
From Ahmed HU et al., J Urol, 2011; 186(2):
Contemporary Clinical Trials  , 26-40DOI: ( /j.cct )
Copyright © 2015 The Authors Terms and Conditions

9. Fig. 8
Illustration summarizing some of the assumptions made in determining sample size calculations for the primary outcome.
Contemporary Clinical Trials  , 26-40DOI: ( /j.cct )
Copyright © 2015 The Authors Terms and Conditions