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Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement  Vitoon Saengsirisuwan, Somrudee Pongseeda,

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Presentation on theme: "Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement  Vitoon Saengsirisuwan, Somrudee Pongseeda,"— Presentation transcript:

1 Modulation of insulin resistance in ovariectomized rats by endurance exercise training and estrogen replacement  Vitoon Saengsirisuwan, Somrudee Pongseeda, Mujalin Prasannarong, Kanokwan Vichaiwong, Chaivat Toskulkao  Metabolism - Clinical and Experimental  Volume 58, Issue 1, Pages (January 2009) DOI: /j.metabol Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Fig. 1 Glucose (A) and insulin (B) responses during an OGTT, AUC for glucose (C) and insulin (D), and the G-I index (E) in SHAM and OVX rats that received E2, ET, and E2 + ET. Data for AUC were calculated from glucose (A) and insulin (B) responses. The G-I index was the product of glucose AUC and insulin AUC for each individual animal. Values are means ± SE for 10 animals per group. ⁎P < .05 vs SHAM group; †P < .05 vs OVX group; #P < .05 OVX vs all other experimental groups; ⁎⁎P < .05 OVX vs OVX + E2, OVX + ET, OVX + E2 + ET; §P < .05 OVX vs OVX + E2, OVX + E2 + ET. Metabolism - Clinical and Experimental  , 38-47DOI: ( /j.metabol ) Copyright © 2009 Elsevier Inc. Terms and Conditions

3 Fig. 2 In vitro rates of 2-DG uptake in SOL (A) and EDL (C) muscles in the absence (blank bars) and presence (filled bars) of insulin (2 mU/mL) and net increase above basal level for 2-DG uptake due to insulin in SOL (B) and EDL (D) muscles of SHAM and OVX rats after receiving E2, ET, and E2 + ET. Values are means ± SE for 10 animals per group. ⁎P < .05 vs SHAM group; †P < .05 vs OVX group. Metabolism - Clinical and Experimental  , 38-47DOI: ( /j.metabol ) Copyright © 2009 Elsevier Inc. Terms and Conditions

4 Fig. 3 Effects of E2, ET, and E2 + ET on whole muscle level of GLUT-4 protein in SOL (A) and EDL (B) muscles from OVX rats. Data of SHAM group were used as control. Values are means ± SE for 10 animals per group. ⁎P < .05 vs SHAM group; †P < .05 vs OVX group. Metabolism - Clinical and Experimental  , 38-47DOI: ( /j.metabol ) Copyright © 2009 Elsevier Inc. Terms and Conditions

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