1. Central role for Cdc42 in yeast budding
Park and Bi, 2007

2. Conserved polarity elements
Thompson, 2013

3. Early asymmetry in C. elegans
Kemphues, 2000

4. Par proteins and asymmetry
Munro and Bowerman, 2009

5. Asymmetry of cell division

6. Asymmetric distribution of par proteins
Par6-GFP
Par2-GFP
Munro et al., 2004
Schonegg and Hyman, 2006

7. Asymmetric myosin and Cdc42 flow
Nmy2-GFP
Cdc42-GFP
Munro et al., 2004
Schonegg and Hyman, 2006

8. Jenkins et al., 2006

9. Thompson, 2013

10. Epithelial organs form lumens

11. The three epithelial polarity complexes
Humbert et al., 2008

12. PIP distribution in migrating cells

13. PIP distribution in epithelia

14. References
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Humbert PO, Grzeschik NA, Brumby AM, Galea R, Elsum I, Richardson HE. (2008). Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module. Oncogene. 27:
Kemphues K. (2000). PARsing embryonic polarity. Cell. 101:345-8.
Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K. (2007). PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell. 128:
Motegi F, Sugimoto A. (2006). Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos. Nat Cell Biol. 8:
Munro E, Bowerman B. (2009). Cellular symmetry breaking during Caenorhabditis elegans development.
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Munro E, Nance J, Priess JR. (2004). Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo. Dev Cell. 7:
Park HO, Bi E. (2007). Central roles of small GTPases in the development of cell polarity in yeast and beyond. Microbiol Mol Biol Rev. 71:48-96.
Schonegg S, Hyman AA. (2006). CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos. Development. 133:
Thompson BJ. (2013). Cell polarity: models and mechanisms from yeast, worms and flies. Development. 140:13-21.