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Cartoon illustrating the nonsuperimposibility of the two stereoisomers of carvedilol on the β receptor. The "receptor surface" has been grossly oversimplified.

Published byLogan McKenzie Modified over 6 years ago

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Presentation on theme: "Cartoon illustrating the nonsuperimposibility of the two stereoisomers of carvedilol on the β receptor. The "receptor surface" has been grossly oversimplified."— Presentation transcript:

1 Cartoon illustrating the nonsuperimposibility of the two stereoisomers of carvedilol on the β receptor. The "receptor surface" has been grossly oversimplified. The chiral center carbon is denoted with an asterisk. One of the two isomers fits the three-dimensional configuration of binding site of the β-adrenoceptor molecule very well (left), and three groups, including an important polar moiety (an hydroxyl group, indicated by the central dashed line), bind to key areas of the surface. The less active isomer cannot orient all three binding areas to the receptor surface (right). (Molecule generated by means of Jmol, an open-source Java viewer for chemical structures in 3D [ with data from DrugBank [ Source: Chapter 1. Introduction, Basic & Clinical Pharmacology, 12e Citation: Katzung BG, Masters SB, Trevor AJ. Basic & Clinical Pharmacology, 12e; 2012 Available at: Accessed: October 28, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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