1. REVOLUTiONiZiNG MALARiA VACCiNATiON
Photo credit:: PATH Malaria Vaccine inniciative

2. Company
Founders
Business development
advisors

3. Support 100 thousand US$ 1.2 million US$ 320 thousand US$
Phase I funding
100 thousand US$
(November 2010)
Phase II funding
1.2 million US$
(November 2013)
Supplement to
320 thousand US$
(December 2014)
Pre-clinical safety studies
280 thousand US$
(February 2016)

4. Problem
MALARIA
2.5 billion people at risk of contracting malaria
700 thousand deaths
every year
12 billion US$ in lost GDP of endemic countries
NO EFFECTIVE VACCINE
AVAILABLE
Most advanced candidate only affords ~36% protection against
a single parasite species
Photo credit: Antonio M. Mendes

5. 4.5 billion US$ global market
Market potential
4.5 billion US$ global market
Humanitarian market:
(estimated value: 3 billion US$)
Private market:
(estimated value: 700 million US$)
Tourist & military market:
(estimated value: 800 million US$)
Photo credit: NYtimes

6. Whole organism vaccines
Vaccine Approaches
Whole
organism
vaccines
Shown to confer >90% sterile protection against a new infection in Phase I/IIa trials
Serious safety
concerns
Extremely high
dosages
Do not target the most prevalent parasite, P. vivax
Mandatory high biosafety BSL3
production facilities

7. WHOLE-ORGANISM PLATFORM FOR VACCINATION AGAINST
Uniqueness
Plasmodium
berghei
A SAFE & VERSATILE
WHOLE-ORGANISM PLATFORM
FOR VACCINATION AGAINST
MULTIPLE HUMAN
PARASITES
Photo credit: worldnaturephoto.com

8. Pre-clinical data

9. Stakeholders

10. New Vaccine Candidates
Capable of blocking parasite development at various stages of their life cycle

11. Production & delivery Establishment of
cell culture-based production of sporozoites
Development of a vaccine cryopreservation system

12. Cryopreservation system

13. Cell-culture-based production of sporozoites
400
300
200
100 3 5 10 12 15 18 21 25
Time (days)
Luminescence (% of d0)
d10 d3
d12 d5
d21

14. Strategy Vaccine Clinical Development (Market entry: 2025)
Production & delivery technology
(Market entry: 2018)

15. LET’S PUT AN
END TO MALARiA
Photo credit: Antonio M. Mendes