1. Profiling counterfeit Cialis, Viagra and analogs by UPLC–MS
Rafael S. Ortiz, Kristiane de Cássia Mariotti, Maribete H. Holzschuh, Wanderson Romão, Renata P. Limberger, Paulo Mayorga 
Forensic Science International 
Volume 229, Issue 1, Pages (June 2013)
DOI: /j.forsciint
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2. Fig. 1
Samples used in the study: counterfeit Viagra (of seizures A, B and E), authentic Viagra® (S), counterfeit Cialis (of seizures G, I and J) and authentic Cialis® (T).
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3. Fig. 2
Chromatograms obtained for SLD (0.48 and 0.57min) and TAD (1.15 and 1.22min) solutions (central point of linearity curve) from UV and ESI(+)MS spectra, respectively. In top, it is visualized UV spectra for (a) SLD and (b) TAD with maxima at 223 and 293nm for SLD and 283nm for TAD. In bottom is shown the ESI(+)-MS spectra for ions (c) [SLD+H]+ of m/z and (d) [TAD+H]+ of m/z
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4. Fig. 3
DAD chromatograms for (a) authentic Viagra®, (b) counterfeit Viagra, (c) authentic Cialis® and (d) counterfeit Cialis containing SLD and TAD. For each chromatogram is indicated the retention time, peak purity, maximum value in DAD UV spectrum and integrate peak area. An insert is shown in panel b for second peak at 0.77min where the ESI(+)-MS detected a ion of m/z 489 (sample A9).
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5. Fig. 4
Chemical structures of some PDE-5 inhibitors (a) and respective UV spectrum (b)
Source: Adapted from Zou et al. [16].
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6. Fig. 5
Mean plot for API concentration in μgmg−1 (w/w) for 108 samples in this study: counterfeit Viagra (A–F), counterfeit Cialis (G–M) and commercial brands (N–Z) including authentic Viagra (S) and authentic Cialis (T).
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7. Fig. 6
2D PCA scores for 108 samples: a classification into of 5 groups was observed.
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8. Fig. 7
Dendrogram representing HCA for the 64 counterfeits samples (single linkage, Euclidean distance). In red, clusters with elements of different apprehensions and normalized distance less than 10. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.)
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