1. Chinese medicinal herbs: treatments or toxins?
Dr. Lunn
Julie Alex

2. Finding drugs Target + Screening libraries Artificial compounds
Traditional Medicine as a guide

3. Chinese medicine Yin and Yang Inner imbalance shown through disease
Herbal Medicines
Acupuncture
Moxibustion
Tui na
Dietary therapy
Tai chi, qi gong
Cupping

4. NIH

5. Plant Genus Aconitum (over 250 species)
Aconite, monkshood, wolf's bane, leopard's bane, women's bane, devil's helmet, Queen of all Poisons, or blue rocket
Used to for hunting/warfare (bows and lances)
Name from the Greek word ἀκόνιτον meaning “Without struggle”
Northern Hemisphere

6. Fu zi (Aconiti Lateralis Radix Praeparata)
Prepared Aconite root
Genus Aconitum and Family Ranunculaceae
Located in China
Acontium carmichaeli
Aconite (2mg) or plant (1g)

7. Chinese uses

8. Components
Aconitine, chasmanine, crassicauline A, oxonitine, deoxyaconitine, hypaconitine, mesaconitine, senbusine A, and two atisine-type C20-diterpenoid alkaloids, songoramine, and 15-cetylsongoramine

9. Clinical TRial
Clinical research of Dahuang Fuzi decoction in auxiliary treatment of severe acute pancreatitis: a multi-center observation in 206 patients
Zhongshan Hospital (Liaoning, China)
Soapsuds enema control group (control group, n=101) and Dahuang Fuzi decoction enema study group (study group, n=105).
Measurements include endotoxin, high-sensitive C-reactive protein, immunoglobulin (IgG, IgA, IgM), complements (C3, C4), tumour necrosis factor-α (TNF-α), interleukins (IL-6, IL-8)
Additional studies include bowel sound, gastrointestinal function score, the acute physiology and chronic health evaluation II (APACHEII) score and the length of mechanical ventilation (MV), the length of stay in ICU, the mortality rate and average hospital expenses
Efficacy assayed before and after treatment for 2, 4, 7 days
Results: body immunity was enhanced, intestinal peristalsis was enhanced, the 28-day mortality and average hospital expenses were lowered

10. Proposal
Is the efficacy of this plant due to one specific compound or is it a joint-effect due to the combination of several compounds? If a mix, which compounds would react together to have the desired effect?
Looking into different forms of procedures that will reduce the toxicity of the herb.

11. Work cited http://www.allfordrugs.com/fdas-drug-review-process/:
://theory.yinyanghouse.com/theory/herbalmedicine/fu_zi_tcm_herbal_database
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