1. From: Nanosponge-Mediated Drug Delivery Lowers Intraocular Pressure
Trans. Vis. Sci. Tech ;4(1):1. doi: /tvst.4.1.1
Figure Legend:
Intravitreal injection of brimonidine NS lowers IOP. (A) Topical application of brimonidine once daily lowered IOP on days 5 and 6 compared to saline-treated eyes (*P < 0.001, n = 3). Stopping treatment on day 7 caused IOP to increase. Resuming treatment on day 12 lowered IOP compared to saline-treated eyes by day 18 (**P < 0.017). (B) Intravitreal injection of brimonidine on day 4 lowered IOP compared to intravitreal saline injection (*P < 0.027, n = 3). (C) Intravitreal injection of brimonidine NS on day 2 lowered IOP by day 4 compared to intravitreal saline injection (*P < 0.002, n = 5). The IOP in the NS eye remained lower than saline-injected eyes until day 10 (**P < 0.02). inj, microbead injection; trx, brimonidine treatment. (D) Line graph comparing the difference in IOP between saline- and brimonidine-treated eyes (Δ IOP) for each delivery method. Treatment began on day 0. *P = (topical versus intravitreal delivery) or **P = (topical versus NS delivery). n = 3 for topical and intravitreal, n = 5 for NS.
Date of download: 10/26/2017
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