1. Edward Peirson Richardson, JR. (1918 – 1998)
History of Neurology
Edward Peirson Richardson, JR.
(1918 – 1998)
Richard J. Barohn, MD
Gertrude and Dewey Ziegler Professor of Neurology
The University of Kansas Medical Center

2. Edward Peirson Richardson Jr., MD (1918-1998)
From a long line of HMS scholars/faculty:
Father & Paternal Grandfather Chiefs of MGH surgery
Mother: Clara Lee Shattuck; he was the 6th Shattuck physician & Shattuck street is where HMS is located
1939 Harvard & 1943 HMS
1944 – 1946: Served in WWII as a physician
1946: MGH Psychiatry Resident under Dr. Stanley Cobb
1947: Queens Square Neurology & Maudsley Hospital for Psychiatry
Queen Square-exposed to Dr. J. Goodwin Greenfield Neuropathology
1949: MGH Asstistant to Dr. Charles Kubik in Neuropathology
1951 – 1989: Neuropathology Lab Director
Worked with Adams, Miller Fisher, Castlemen, & Victor
Continued to work until a few months before his death from lymphoma
1984: Bullard Professor of Neuropathology

3. Edward Peirson Richardson Jr., MD (1918-1998)
MGH residents all did 1 year Neuropathology for many years & were trained by EPR
He taught Neuropathology courses at HMS for 2nd year medical students with RD Adams, MD & Alfred Pope, MD
Also taken by all Neuropathology trainees - Neurology and Path residents
Frequent contributor to Pathology section of NE Journal of Medicine & CPCs
Led Neuropathology teaching sessions/brain cutting during Tuesday evening conferences
Neurology. 1967;17(8 Pt 2):22-5

4. Edward Peirson Richardson Jr., MD Major Contributions
Progressive Multifocal Leukoencephalopathy
Papers 1961 & 1988
Described what was then a new entity
Corticobasal Degeneration. Arch Neurol 1968;18:20-33
The myelopathy of pernicious anemia: A neuropathological reappraisal. Acta Neurol Scand. 1968;44:Suppl 5:1-36
Granulomatous angiitis of the central nervous system: Protean manifestations and response to treatment. 1988; 51(9): 1126– 1133
Granulomatous angiitis of the central nervous system. Arch Neurol. 1968; 19:
The neurological manifestations of systemic lupus erythematosus. Medicine Jul;47(4):337-69
Pathogenesis and evolution of periventricular leukomalacia in infancy. Arch Neurol. 1972;27:
Adreno-leukodystrophy (Sex-Linked Schilder Disease) Ultrastructural Demonstration of Specific Cytoplasmic Inclusions in the Central Nervous System. Arch Neurol. 1972;27:
Adrenoleukodystrophy: A clinical and pathological study of 17 cases. Arch Neurol. 1975; 32:
Hallervorden-Spatz syndrome. Arch Neurol. 1974 Jan;30(1):70-83
Subacute diencephalic angioencephalopathy. J Neurol Sci. 1974;22:

5. Edward Peirson Richardson Jr., MD Major Contributions (cont.)
Spinal epidural abscess. N Engl J Med. 1975 Sep 4;293(10):463-8
Hypoxic-Ischemic Leukoencephalopathy in Man. Arch Neurol. 1976;33(1):5-14
Subacute Spongiform Encephalopathy: Creutzfeldt-Jakob Disease. Brain ;101(2):
Subacute encephalomyelitis of AIDS and its relation to HTLV‐III infection. Neurology. 1987;37:
Selective sparing of a class of striatal neurons in Huntington's disease. Science ;230:
Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol. 1985;44:
Clinical and neuropathologic assessment of severity in Huntington's disease. Neurology. 1988;38:
Pathology of the Peripheral Nerve (1995)
The Neurologic Illness of Eugene O'Neill. N Engl J Med. 2000;343:

6. Letter Written for Dr. Barohn from EP Richardson

7. Pictures from Tyler Library
RD Adams MD
E.P. Richardson MD
C Miller Fisher, MD
Harvey Cushing MD

8. Elliot Richardson (1920-1999) Who was Elliot Richardson????
Former President of Harvard
Former Secretary of State
Former Attorney General
EP Richardson's Father
Answer: C - Former Attorney General in 1973

9. Elliot Richardson: What is he known for?
Allowed minority students in Harvard
Helped President Kennedy in Cuban Missile Crises
Fired by President Nixon in “Saturday Night Massacre” when he refused to fire Archibald Cox, the Watergate prosecutor
Nothing
Answer: C - Fired by Nixon in “Saturday Night Massacre” when he refused to fire Archibald Cox, the Watergate prosecutor
Also EP Richardson’s Brother